I5659

Idevenone

≥98% (HPLC), powder

• Sinónimos: 2-(10-hydroxydecyl)-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione
• Fórmula empírica (notación de Hill): C₁₉H₃₀O₅
• Número de CAS: 58186-27-9
• Peso molecular: 338.44
• Número MDL: MFCD00274552
• Código UNSPSC: 12352204
• ID de la sustancia en PubChem: 329815386
• NACRES: NA.25

Propiedades

• Nombre del producto: Idevenone, ≥98% (HPLC)
• Ensayo: ≥98% (HPLC)
• Formulario: powder
• solubilidad: methanol: 50 mg/mL, clear to slightly hazy
• temp. de almacenamiento: room temp
• cadena SMILES: O=C(C(OC)=C1OC)C(CCCCCCCCCCO)=C(C)C1=O
• InChI: 1S/C19H30O5/c1-14-15(12-10-8-6-4-5-7-9-11-13-20)17(22)19(24-3)18(23-2)16(14)21/h20H,4-13H2,1-3H3
• Clave InChI: JGPMMRGNQUBGND-UHFFFAOYSA-N

Descripción

Descripción general

Idebenone is a short-chain benzoquinone drug.[1]

Aplicación

Idebenone has been used:

• to treat mutant myocilin (mMYOC) cells for drug treatment assay[2]
• to validate C2C12 secondary cell screening assay[3]
• to treat obese mice, to test whether idebenone and CoQ10 bind directly to peroxisome proliferator-activated receptor (PPAR)LBDs, His-tagged PPARα, δ and γ LBDs[4]

Acciones bioquímicas o fisiológicas

A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.

Idebenone is used in the treatment of visual impairment in adolescents and adults with Leber′s hereditary optic neuropathy (LHON).[1] It serves as an antioxidant. It helps to guard the heart muscle against oxidative stress.[5]

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable