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Merck

D7821

Sigma-Aldrich

dPPA

≥98% (HPLC)

Sinónimos:

12-Deoxyphorbol 13-phenylacetate 20-acetate, DOPPA

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10 MG
ILS 1.813,00
25 MG
ILS 3.985,00
50 MG
ILS 4.172,00

ILS 1.813,00


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10 MG
ILS 1.813,00
25 MG
ILS 3.985,00
50 MG
ILS 4.172,00

About This Item

Fórmula empírica (notación de Hill):
C30H36O7
Número de CAS:
Peso molecular:
508.60
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77

ILS 1.813,00


Disponibilidad
Póngase en contacto con nuestro Servicio de Atención al Cliente para disponibilidad

Quality Level

assay

≥98% (HPLC)

form

oil

color

colorless to light yellow

storage temp.

−20°C

SMILES string

CC(C1=O)=C[C@]2([H])[C@]1(O)CC(COC(C)=O)=C[C@]3([H])[C@]2(O)[C@H](C)C[C@]4(OC(CC5=CC=CC=C5)=O)[C@H]3C4(C)C

InChI

1S/C30H36O7/c1-17-11-23-28(34,26(17)33)15-21(16-36-19(3)31)12-22-25-27(4,5)29(25,14-18(2)30(22,23)35)37-24(32)13-20-9-7-6-8-10-20/h6-12,18,22-23,25,34-35H,13-16H2,1-5H3/t18-,22+,23-,25-,28-,29+,30-/m1/s1

InChI key

MEDVHSNRBPAIPU-XMOZQXTISA-N

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Este artículo
434929015767902
application(s)

environmental
food and beverages

application(s)

environmental
food and beverages

application(s)

environmental
food and beverages

application(s)

environmental
food and beverages

format

single component solution

format

single component solution

format

single component solution

format

single component solution

Quality Level

300

Quality Level

300

Quality Level

300

Quality Level

300

grade

certified reference material, TraceCERT®

grade

certified reference material, TraceCERT®

grade

certified reference material, TraceCERT®

grade

certified reference material, TraceCERT®

concentration

1000 mg/L Ni+2 in nitric acid (nominal concentration)

concentration

1000 mg/L Na+ in water (nominal concentration)

concentration

1000 mg/L cyanide in water (nominal concentration)

concentration

1000 mg/L Zn+2 in nitric acid (nominal concentration)

Application

dPPA/phorbol ester 12-deoxyphorbol 13-phenylacetate 20-acetate (DOPPA) may be used as a potent activator of PKC-β:
  • to treat transfected HT-22 cells to promote phosphorylation of p66Shc[1]
  • to treat HT-22 and B12 cells to study its effects on cell viability[1]
  • to treat neurons and measure primary cortical neurons using the 2,5-diphenyl-2H-tetrazolium bromide (MTT) assay[1]

Biochem/physiol Actions

dPPA is a phorbol ester that selectively activates the β isotype of PKC. It is approximately 100-fold more potent for PKC-β than the α, γ or δ isotypes. PKC family members each have specific functions, but PKC-β and δ appear to share similar expression profiles, and both are involved in regulating apoptosis and B cell activation, thus dPPA is a useful tool in determining PKCβ specific signaling events.

Features and Benefits

This compound is featured on the PKC page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

pictograms

Skull and crossbones

signalword

Danger

Hazard Classifications

Acute Tox. 1 Inhalation - Acute Tox. 2 Dermal - Acute Tox. 2 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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    Los clientes también vieron

    S Aggarwal et al.
    Journal of clinical immunology, 14(4), 248-256 (1994-07-01)
    To determine a role of protein kinase C (PKC) isozymes in lymphocyte activation, human peripheral blood mononuclear cells were activated with 12-deoxyphorbol-13-O-phenylacetate (dPP; an agonist of both calcium-dependent and calcium-independent PKC isozymes), thymeleatoxin (TX; an activator of calcium-dependent PKC alpha
    Y Masuda et al.
    International journal of cancer, 71(4), 691-697 (1997-05-16)
    In a previous study, we showed that geranylgeraniol (GGO) is a potent inducer of apoptosis in human leukemia cells, including HL60 promyelocytic leukemia cells. The present study describes the effects of activators of protein kinase C (PKC) on GGO-induced apoptosis
    T Husøy et al.
    Carcinogenesis, 22(2), 221-231 (2001-02-22)
    12-O:-tetradecanoylphorbol-13-acetate (TPA) inhibits gap junctional communication in many cell culture systems, but TPA-induced phosphorylation of the gap junction protein connexin43 (Cx43) varies much between systems. We have here studied whether these responses and their sensitivities can be correlated with total
    E M Williamson et al.
    Acta pharmacologica et toxicologica, 48(1), 47-52 (1981-01-01)
    The pro-inflammatory tigliane esters 12-deoxyphorbolphenylacetate (12-DOPPA) and 12-deoxyphorbolphenylacetate-20-acetate (12-DOPPAA) at a dose of 0.1 microgram induced erythema in the mouse ear. Observations of ear redness were made both two and four hours after application. Indomethacin was only partly successful as
    R N Cortright et al.
    American journal of physiology. Endocrinology and metabolism, 278(3), E553-E562 (2000-03-11)
    There is good evidence from cell lines and rodents that elevated protein kinase C (PKC) overexpression/activity causes insulin resistance. Therefore, the present study determined the effects of PKC activation/inhibition on insulin-mediated glucose transport in incubated human skeletal muscle and primary

    Artículos

    Protein kinase C (PKC) is an AGC kinase that phosphorylates serine and threonine residues in many target proteins.

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