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Documentos

C9187

Sigma-Aldrich

Cys-Gly, oxidized

≥95% (HPLC)

Sinónimos:

Cys(Cys-Gly)-Gly

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About This Item

Fórmula empírica (notación de Hill):
C10H18N4O6S2
Número de CAS:
7729-20-6
Peso molecular:
354.40
UNSPSC Code:
12352200
PubChem Substance ID:
24893139
NACRES:
NA.26

assay

≥95% (HPLC)

form

powder

color

white

storage temp.

−20°C

SMILES string

NC(CSSCC(N)C(=O)NCC(O)=O)C(=O)NCC(O)=O

InChI

1S/C10H18N4O6S2/c11-5(9(19)13-1-7(15)16)3-21-22-4-6(12)10(20)14-2-8(17)18/h5-6H,1-4,11-12H2,(H,13,19)(H,14,20)(H,15,16)(H,17,18)

InChI key

KDJVKDYFFTWHBO-UHFFFAOYSA-N

Biochem/physiol Actions

Cys(Cys-Gly)-Gly is the reversibly oxidized form of Cys-Gly. L-Cysteine-L-Glycine (Cys-Gly) is used in studies on the homeostasis of glutathione. Cys-Gly is an important molecule for study in the areas of thiol homeostasis, oxidative stress and metals management.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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L-Glutationa oxidada ≥98% (HPLC)

Sigma-Aldrich

G4376

L-Glutationa oxidada

Hardeep Kaur et al.
The Journal of biological chemistry, 284(21), 14493-14502 (2009-04-07)
GSH metabolism in yeast is carried out by the gamma-glutamyl cycle as well as by the DUG complex. One of the last steps in the gamma-glutamyl cycle is the cleavage of Cys-Gly by a peptidase to the constitutent amino acids.
Hardeep Kaur et al.
Biochimie, 93(2), 175-186 (2010-09-28)
Dug1p is a recently identified novel dipeptidase and plays an important role in glutathione (GSH) degradation. To understand the mechanism of its substrate recognition and specificity towards Cys-Gly dipeptides, we characterized the solution properties of Dug1p and studied the thermodynamics
Thomas Müller et al.
Movement disorders : official journal of the Movement Disorder Society, 26(3), 543-546 (2011-04-05)
Oxidative stress is influenced by the thiol homeostasis, which determines the redox milieu. One of its components is Cysteinyl-glycine (Cys-Gly) generation, as its metabolic precursor is the free radicals scavenging glutathione. Levodopa is under suspicion to promote oxidative stress via
Elena Chekmeneva et al.
Metallomics : integrated biometal science, 3(8), 838-846 (2011-06-21)
Isothermal Titration Calorimetry (ITC) was used to study the binding of Cd(2+) by phytochelatins ((γGlu-Cys)(n)-Gly, PC(n); n = 1-5) and their selected fragments (Cys, Cys-Gly and γGlu-Cys) in order to understand the influence of the chain length on the complex

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