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Merck

C239

CNQX disodium salt hydrate

≥98% (HPLC), solid, AMPA/kainate receptor antagonist.

Sinónimos:

6-Cyano-7-nitroquinoxaline-2,3-dione disodium salt hydrate

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5 MG

US$ 203,00

25 MG

US$ 637,00

100 MG

US$ 1.480,00

US$ 203,00

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Fórmula empírica (notación de Hill):
C9H2N4Na2O4 · xH2O
Número CAS:
115066-14-3
Peso molecular:
276.12 (anhydrous basis)
UNSPSC Code:
12352200
PubChem Substance ID:
24277972
NACRES:
NA.77
MDL number:
MFCD09953908
Assay:
≥98% (HPLC)
Form:
solid
Quality level:
100
Storage condition:
protect from light

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Nombre del producto

CNQX disodium salt hydrate, ≥98% (HPLC), solid

SMILES string

O.[Na+].[Na+].[O-]c1nc2cc(C#N)c(cc2nc1[O-])[N+]([O-])=O

InChI

1S/C9H4N4O4.2Na.H2O/c10-3-4-1-5-6(2-7(4)13(16)17)12-9(15)8(14)11-5;;;/h1-2H,(H,11,14)(H,12,15);;;1H2/q;2*+1;/p-2

InChI key

LCDWHGXMFAZHEO-UHFFFAOYSA-L

assay

≥98% (HPLC)

form

solid

storage condition

protect from light

color

orange to red

solubility

H2O: >2 mg/mL (warmed)

Quality Level

100

Gene Information

human ... ADORA1(134), ADORA2A(135), ADORA2B(136), ADORA3(140), GRIA1(2890), GRIA2(2891), GRIA3(2892), GRIA4(2893)

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Este artículo
C127N183M3568
CNQX disodium salt hydrate ≥98% (HPLC), solid

Sigma-Aldrich

C239

CNQX disodium salt hydrate

CNQX ≥98% (HPLC), solid

Sigma-Aldrich

C127

CNQX

NBQX disodium salt hydrate ≥98% (HPLC)

Sigma-Aldrich

N183

NBQX disodium salt hydrate

MSX-3 hydrate ≥98% (HPLC), solid

Sigma-Aldrich

M3568

MSX-3 hydrate

form

solid

form

solid

form

lyophilized powder

form

solid

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

solubility

H2O: >2 mg/mL (warmed)

solubility

DMSO: >10 mg/mL, H2O: insoluble

solubility

H2O: >10 mg/mL

solubility

H2O: soluble >5 mg/mL at 60 °C

storage condition

protect from light

storage condition

protect from light

storage condition

desiccated

storage condition

protect from light

color

orange to red

color

yellow

color

, brown to dark red-brown

color

pale yellow

Application

CNQX disodium salt hydrate has been used as:
  • as a competitive non-NMDA receptor antagonist and competitive AMPA/kainate receptor antagonist in neuronal cultures(110)
  • as a glutamatergic blockers for measuring inhibitory postsynaptic currents in projection neurons(111)
  • as a AMPA glutamate receptor antagonist prefrontal cortex neurons(112)

Biochem/physiol Actions

Potent, competitive AMPA/kainate receptor antagonist.
CNQX(6-cyano-7-nitroquinoxaline-2,3-dioneis) is a potent, competitive AMPA/kainate receptor antagonist. It is a quinoxaline derivative and also an antagonist for non-N-methyl-d-aspartate (non-NMDA) glutamate receptor. CNQX mediates depolarization thalamic reticular nucleus via α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors (AMPARs). It displays micromolar affinity towards AMPA/kainate receptor.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificados de análisis (COA)

Lot/Batch Number
0000446243
0000446226
0000446243
0000440772
0000440772

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Visite la Librería de documentos

Medicinal chemistry of competitive kainate receptor antagonists
Larsen, Ann M and Bunch, Lennart
ACS Chemical Neuroscience, 2(2), 60-74 (2010)
CNQX Blocks Kainate-induced Corneal Irritation
Ibitokun, Bernadette O and Miller, Kenneth E
investigate opthalmology and visual science, 53(14), 1855-1855 (2012)
Selective excitatory actions of DNQX and CNQX in rat thalamic neurons
Lee SH, et al.
Journal of Neurophysiology, 103(4), 1728-1734 (2010)
Teri M Furlong et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(14), 5012-5022 (2014-04-04)
Access to highly palatable and calorically dense foods contributes to increasing rates of obesity worldwide. Some have made the controversial argument that consumption of such foods can lead to "food addiction," yet little is known about how long-term access to
Alessandro Sanzeni et al.
eLife, 9 (2020-07-01)
Many cortical network models use recurrent coupling strong enough to require inhibition for stabilization. Yet it has been experimentally unclear whether inhibition-stabilized network (ISN) models describe cortical function well across areas and states. Here, we test several ISN predictions, including
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