Unfortunately, this item is not tested for the suitability of cell culture applications. There is no cell culture-tested product option at this time.
37095
Staurosporine
VETRANAL®, analytical standard
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10 MG
US$ 2.690,00
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10 MG
US$ 2.690,00
About This Item
Fórmula empírica (notación de Hill):
C28H26N4O3
Número de CAS:
Peso molecular:
466.53
Número MDL:
Código UNSPSC:
41116107
ID de la sustancia en PubChem:
NACRES:
NA.24
Productos recomendados
grado
analytical standard
Nivel de calidad
Línea del producto
VETRANAL®
caducidad
limited shelf life, expiry date on the label
técnicas
HPLC: suitable
gas chromatography (GC): suitable
aplicaciones
forensics and toxicology
pharmaceutical (small molecule)
Formato
neat
temp. de almacenamiento
−20°C
cadena SMILES
CN[C@@H]1C[C@@H]2O[C@@](C)([C@@H]1OC)n3c4ccccc4c5c6CNC(=O)c6c7c8ccccc8n2c7c35
InChI
1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20?,26-,28+/m1/s1
Clave InChI
HKSZLNNOFSGOKW-ZGQXJOJZSA-N
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Descripción general
Staurosporine belongs to the class of indolocarbazole alkaloids and shows anti-fungal and anti-oomycete activities. It is isolated from Streptomyces sp. and is known to be a broad-spectrum inhibitor of protein kinase.
Otras notas
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Información legal
VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany
Palabra de señalización
Warning
Frases de peligro
Consejos de prudencia
Clasificaciones de peligro
Aquatic Chronic 4 - Repr. 2
Código de clase de almacenamiento
11 - Combustible Solids
Clase de riesgo para el agua (WGK)
WGK 3
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
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Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.
Karin Anestål et al.
PloS one, 3(4), e1846-e1846 (2008-04-03)
SecTRAPs (selenium compromised thioredoxin reductase-derived apoptotic proteins) can be formed from the selenoprotein thioredoxin reductase (TrxR) by targeting of its selenocysteine (Sec) residue with electrophiles, or by its removal through C-terminal truncation. SecTRAPs are devoid of thioredoxin reductase activity but
A Gescher
General pharmacology, 31(5), 721-728 (1998-11-11)
1. Protein kinase C (PKC) is a family of serine/threonine-directed protein kinases that are pivotal regulators of cellular growth, transformation and death. PKC has therefore been considered to be a suitable target for novel antineoplastic drugs. 2. Twenty years ago
S Ståhl et al.
Cell death & disease, 4, e454-e454 (2013-01-11)
Radiation therapy is frequently used to treat non-small cell lung cancers (NSCLCs). We have previously shown that a combination of ionizing radiation (IR) and the staurosporine analog PKC 412, but not Ro 31-8220, increases cell death in NSCLC cells. To
Staurosporine, K-252 and UCN-01: potent but nonspecific inhibitors of protein kinases.
U T Rüegg et al.
Trends in pharmacological sciences, 10(6), 218-220 (1989-06-01)
Osman A B S M Gani et al.
Natural product reports, 27(4), 489-498 (2010-03-26)
The isolation in 1977 of the microbial alkaloid staurosporine inaugurated research into several distinct series of related natural and synthetic compounds. This has especially included research into applications as anticancer drugs, beginning with the observation of low nanomolar inhibition of
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