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Merck

31493

Sigma-Aldrich

Salicilato de sodio

puriss. p.a., reag. Ph. Eur., 99.5-101.0% (calc. to the dried substance)

Sinónimos:

2-Hidroxibenzoato de sodio, Ácido 2-hidroxibenzoico sodium salt, Ácido salicílico sodium salt

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About This Item

Fórmula lineal:
HOC6H4COONa
Número de CAS:
Peso molecular:
160.10
Beilstein/REAXYS Number:
3732792
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.21

agency

USP/NF
reag. Ph. Eur.

Quality Level

grade

puriss. p.a.

assay

99.5-101.0% (calc. to the dried substance)

impurities

acidic reac. impurities, complies
sulfite or thiosulfate, complies
≤0.001% heavy metals (as Pb)

loss

≤0.3% loss on drying, 105 °C

mp

>300 °C (lit.)

anion traces

chloride (Cl-): ≤20 mg/kg
sulfate (SO42-): ≤500 mg/kg

cation traces

Fe: ≤10 mg/kg

suitability

in accordance for appearance of solution

SMILES string

[Na+].Oc1ccccc1C([O-])=O

InChI

1S/C7H6O3.Na/c8-6-4-2-1-3-5(6)7(9)10;/h1-4,8H,(H,9,10);/q;+1/p-1

InChI key

ABBQHOQBGMUPJH-UHFFFAOYSA-M

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General description

Sodium salicylate can be prepared from the reaction of salicylic acid and ammonia. It exhibits fluorescence at higher concentrations and effectively absorbs β-particles. Due to these properties, it has been employed as fluor for the radioactivity detection in various gels.

Application

Sodium salicylate may be used as phenolic reagent in salicylate method for the determination of ammonia. It may be employed as a hydrotropic agent to study the release of anticancer drug camptothecin (CPT) from the mixed micelles [composed of Pluronic P105 (P105) and D-α-tocopheryl polyethylene glycol 1000 succinate (TPGS)].

pictograms

Health hazardExclamation mark

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Repr. 2

Storage Class

11 - Combustible Solids

wgk_germany

WGK 1

flash_point_f

208.9 °F - Pensky-Martens closed cup

flash_point_c

98.3 °C - Pensky-Martens closed cup

ppe

dust mask type N95 (US), Eyeshields, Gloves


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Yan Gao et al.
Colloids and surfaces. B, Biointerfaces, 64(2), 194-199 (2008-03-08)
To increase the solubility and cytotoxicity of poorly soluble anticancer drug camptothecin (CPT), mixed micelles made of Pluronic P105 (P105) and d-alpha-tocopheryl polyethylene glycol 1,000 succinate (TPGS) were prepared. The interaction of Pluronic and TPGS was studied and critical micelle
Ammonia determination based on indophenol formation with sodium salicylate.
Verdouw H, et al.
Water Research, 12(6), 399-402 (1978)
Fluorographic detection of radioactivity in polyacrylamide gels with the water-soluble fluor, sodium salicylate.
J P Chamberlain
Analytical biochemistry, 98(1), 132-135 (1979-09-15)
Kui Wang et al.
Journal of medicinal chemistry, 52(20), 6402-6412 (2009-10-16)
Viologens are showing an increasing number of scientific and technical applications in addition to their use as herbicides. However, their high toxicity poses considerable risks to human health, society, and the environment. In this context, we propose a new therapeutic
Rainer Amann et al.
European journal of pharmacology, 447(1), 1-9 (2002-07-11)
Aspirin (acetylsalicylic acid) is one of the most widely used drugs worldwide. It acetylates cyclooxygenases thereby irreversibly blocking the conversion of arachidonic acid to prostanoids. Biotransformation of aspirin yields salicylate, a compound that possesses similar anti-inflammatory potency as aspirin but

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