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MAB5490

Sigma-Aldrich

Anti-Huntingtin Antibody, a.a. 115-129

ascites fluid, Chemicon®

Sinónimos:

Anti-HD

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

mouse

antibody form

ascites fluid

antibody product type

primary antibodies

clone

monoclonal

species reactivity

human

manufacturer/tradename

Chemicon®

technique(s)

ELISA: suitable
immunocytochemistry: suitable
immunohistochemistry: suitable
western blot: suitable

isotype

IgG1κ

NCBI accession no.

NM_002111.6

UniProt accession no.

P42858

shipped in

dry ice

target post-translational modification

unmodified

Gene Information

human ... HTT(3064) , SLC6A4(6532)

Specificity

Reacts huntingtin protein, amino acids 115-129. The antibody recognizes wild type and mutant huntingtin.

Immunogen

Epitope: a.a. 115-129
Recombinant human huntingtin, amino acids 115-129.

Application

Anti-Huntingtin Antibody, a.a. 115-129 detects level of Huntingtin & has been published & validated for use in ELISA, WB, IC, IH.
Research Category
Neuroscience
Research Sub Category
Neurodegenerative Diseases
Western blot: 1:500-1:5,000

Immunocytochemistry (1): 1:500-1:5,000

Immunohistochemistry (1,2): 1:500-1:5,000

ELISA: 1:500-1:5,000

Optimal working dilutions must be determined by end user.

Physical form

Ascites fluid. Liquid. Contains no preservative.

Storage and Stability

Maintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Descripción
Precios

Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Ser46 phosphorylation and prolyl-isomerase Pin1-mediated isomerization of p53 are key events in p53-dependent apoptosis induced by mutant huntingtin.
Grison, A; Mantovani, F; Comel, A; Agostoni, E; Gustincich, S; Persichetti, F; Del Sal, G
Proceedings of the National Academy of Sciences of the USA null
Katarina Trajkovic et al.
Bio-protocol, 8(1) (2018-01-13)
Quantitative analysis of proteins secreted from the cells poses a challenge due to their low abundance and the interfering presence of a large amount of bovine serum albumin (BSA) in the cell culture media. We established assays for detection of
Tamara Ratovitski et al.
Cell cycle (Georgetown, Tex.), 14(11), 1716-1729 (2015-05-01)
Abnormal protein interactions of mutant huntingtin (Htt) triggered by polyglutamine expansion are thought to mediate Huntington's disease (HD) pathogenesis. Here, we explored a functional interaction of Htt with protein arginine methyltransferase 5 (PRMT5), an enzyme mediating symmetrical dimethylation of arginine
Jacqueline Gire O'Rourke et al.
Cell reports, 4(2), 362-375 (2013-07-23)
A key feature in Huntington disease (HD) is the accumulation of mutant Huntingtin (HTT) protein, which may be regulated by posttranslational modifications. Here, we define the primary sites of SUMO modification in the amino-terminal domain of HTT, show modification downstream of
IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome.
Thompson, LM; Aiken, CT; Kaltenbach, LS; Agrawal, N; Illes, K; Khoshnan et al.
The Journal of cell biology null
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