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Sigma-Aldrich

MMP408

≥94% (HPLC), solid, MMP-12 inhibitor, Calbiochem®

Sinónimos:

MMP-12 Inhibitor, MMP408, (S)-2-(8-(Methoxycarbonylamino)dibenzo[b,d]furan-3-sulfonamido)-3-methylbutanoic acid

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About This Item

Fórmula empírica (notación de Hill):
C19H20N2O7S
Número de CAS:
1258003-93-8
Peso molecular:
420.44
UNSPSC Code:
12352200
NACRES:
NA.77

product name

MMP-12 Inhibitor, MMP408, The MMP-12 Inhibitor, MMP408, also referenced under CAS 1258003-93-8, controls the biological activity of MMP-12. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

Quality Level

100

assay

≥94% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

off-white

solubility

DMSO: 100 mg/mL

shipped in

ambient

storage temp.

2-8°C

General description

A dibenzofuranylsulfanamido-valine compound that acts as a potent, active site zinc-targeting, MMP-12-selective inhibitor (IC50 = 2 nM against human MMP-12) with much weaker activity against MMP-12 from mouse/rat/sheep species (IC50 = 160, 320 and 22.3 nM , respectively) or human MMP-3/13/14 (IC50 = 351, 120 and 1100 nM , respectively), and practically ineffective toward human Agg-1/2 (IC50 >5 µM), TACE (IC50 >25 µM), and MMP-1/7 (IC50 >6 µM). MMP408 is orally active in mice and shown to effectively alleviate rhMMP-12-induced pulmonary inflammatory response in mice in vivo by more than 50% (5 mg/kg, p.o., b.i.d.).
A dibenzofuranylsulfanamido-valine compound that acts as a potent, active site zinc-targeting, MMP-12-selective inhibitor (IC50 = 2 nM against human MMP-12) with much weaker activity against MMP-12 from mouse/rat/sheep species (IC50 = 160, 320 and 22.3 nM, respectively) or human MMP-3/13/14 (IC50 = 351, 120 and 1100 nM , respectively), and practically ineffective toward human Agg-1/2 (IC50 >5 µM), TACE (IC50 >25 µM), and MMP-1/7 (IC50 >6 µM). MMP408 is orally active in mice and shown to effectively alleviate rhMMP-12-induced pulmonary inflammatory response in mice in vivo by more than 50% (5 mg/kg, p.o., b.i.d.).

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Li, W., et al. 2009. J. Med. Chem.52, 1799.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Respiratory syncytial virus (RSV) infection often exacerbates bronchial asthma, but there is no licensed RSV vaccine or specific treatments. Here we show that RSV-induced alveolar macrophages, which produce high levels of matrix metalloproteinase-12 (MMP-12), exacerbate allergic airway inflammation with increased
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Matrix metalloproteinases [MMPs] play an important role in extracellular matrix regulation during cell growth and wound healing. Increased expression of MMP-12 [human macrophage elastase] has been reported in inflammatory bowel disease [IBD] which is characterised by the loss of epithelial
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