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444225

Sigma-Aldrich

MMP-3 Inhibitor II

The MMP-3 Inhibitor II, also referenced under CAS 161314-17-6, controls the biological activity of MMP-3. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

Sinónimos:

MMP-3 Inhibitor II, N-Isobutyl-N-(4-methoxyphenylsulfonyl)-glycylhydroxamic Acid, NNGH

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About This Item

Fórmula empírica (notación de Hill):
C13H20N2O5S
Número de CAS:
161314-17-6
Peso molecular:
316.37
MDL number:
MFCD02179370
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

100

assay

≥98% (TLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

color

white

solubility

DMSO: 30 mg/mL
ethanol: 8 mg/mL

shipped in

ambient

storage temp.

10-30°C

General description

A cell-permeable, potent inhibitor of human MMP-3 (stromelysin; Ki = 130 nM).
A potent and cell-permeable inhibitor of human MMP-3 (Ki = 130 nM).

Biochem/physiol Actions

Cell permeable: yes
Primary Target
human MMP-3
Product does not compete with ATP.
Reversible: no
Target Ki: 130 nM against human MMP-3

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Kato, N., et al. 2002. Genome Informatics13, 272.
MacPherson, L.J., et al. 1997. J. Med. Chem. 40, 2525.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Angelika K Lemke et al.
Cell and tissue research, 340(1), 179-188 (2010-03-11)
Pro-inflammatory cytokines induce meniscal matrix degradation and inhibition of endogenous repair mechanisms, but the pathogenic mechanisms behind this are mostly unknown. Therefore, we investigated details of interleukin-1 (IL-1alpha)-induced aggrecan turnover in mature meniscal tissue explants. Fibro-cartilagenous disks (3 mm diameter

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