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D68401

Sigma-Aldrich

2,4-Dichloro-1-nitrobenzene

97%

Sinónimos:

1,3-Dichloro-4-nitrobenzene, asym.-Nitro-m-dichlorobenzene

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About This Item

Fórmula lineal:
Cl2C6H3NO2
Número de CAS:
611-06-3
Peso molecular:
192.00
Beilstein/REAXYS Number:
1451655
EC Number:
210-248-3
MDL number:
MFCD00007071
UNSPSC Code:
12352100
PubChem Substance ID:
24894055

assay

97%

form

solid

bp

258 °C (lit.)

mp

29-32 °C (lit.)

SMILES string

[O-][N+](=O)c1ccc(Cl)cc1Cl

InChI

1S/C6H3Cl2NO2/c7-4-1-2-6(9(10)11)5(8)3-4/h1-3H

InChI key

QUIMTLZDMCNYGY-UHFFFAOYSA-N

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signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 4 Oral - Aquatic Chronic 2 - Carc. 1B - Muta. 2 - Skin Sens. 1B

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Gloves

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V Breinholt et al.
Cancer letters, 154(2), 201-210 (2000-05-12)
The administration of lycopene to female rats at doses ranging from 0.001 to 0.1 g/kg b.w. per day for 2 weeks was found to alter the drug-metabolizing capacity and antioxidant status of the exposed animals. An investigation of four cytochrome
Bruno Miguel Neves et al.
Toxicology letters, 177(1), 74-82 (2008-02-19)
The development of non-animal methods for skin sensitization testing is an urgent challenge. Some of the most promising in vitro approaches are based on the analysis of phenotypical and functional modifications induced by sensitizers in dendritic cell models. In this
Maja Aleksic et al.
Toxicology in vitro : an international journal published in association with BIBRA, 21(4), 723-733 (2007-02-24)
Covalent modification of skin proteins by electrophiles is a key event in the induction of skin sensitisation but not skin irritation although the exact nature of the binding mechanisms has not been determined empirically for the vast majority of sensitisers.
R M Bolton et al.
Analytical biochemistry, 216(2), 418-423 (1994-02-01)
Ammonium 4-chloro-7-sulfobenzofurazan (Sbf-Cl) is a water-soluble fluorescent reagent which is highly specific for thiol groups. We describe here a simple and sensitive fluorescence assay which is highly specific for subunit 3 of the rat glutathione S-transferases. Specific activities of isoenzymes
Teresa J Matos et al.
Journal of dermatological science, 39(2), 113-123 (2005-05-18)
The intracellular mechanisms involved in the activation of DCs during sensitization in allergic contact dermatitis (ACD) are not known. Here, we investigated the effect of a strong sensitizer, 2,4-dinitrofluorobenzene (DNFB) on the activity of MAPKs in a dendritic cell (DC)
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