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Merck
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Documentos

852686

Sigma-Aldrich

6-Mercaptopurine-9-β-D-ribofuranoside

≥95.0% (HPLC)

Sinónimos:

6-Mercaptopurine riboside, 6-Purinethiol riboside, 6-Thioinosine

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About This Item

Fórmula empírica (notación de Hill):
C10H12N4O4S
Número de CAS:
574-25-4
Peso molecular:
284.29
Beilstein/REAXYS Number:
40536
EC Number:
209-371-5
MDL number:
MFCD00005743
UNSPSC Code:
12352200
PubChem Substance ID:
24888331

assay

≥95.0% (HPLC)

form

powder

optical activity

[α]/D −74±4°, c = 1% in 0.1 M NaOH

mp

220-223 °C (lit.)

storage temp.

−20°C

SMILES string

OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n2cnc3c(S)ncnc23

InChI

1S/C10H12N4O4S/c15-1-4-6(16)7(17)10(18-4)14-3-13-5-8(14)11-2-12-9(5)19/h2-4,6-7,10,15-17H,1H2,(H,11,12,19)/t4-,6-,7-,10-/m1/s1

InChI key

NKGPJODWTZCHGF-KQYNXXCUSA-N

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pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

13 - Non Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Lennard P L Gilissen et al.
Journal of Crohn's & colitis, 6(6), 698-707 (2012-03-09)
Therapeutic drug monitoring of active metabolites of thiopurines, azathioprine and 6-mercaptopurine, is relatively new. The proposed therapeutic threshold level of the active 6-thioguanine nucleotides (6-TGN) is ≥235 pmol/8×10(8) erythrocytes. The aim of this prospective cross-sectional study was to compare 6-TGN
M Ben Sghaier et al.
Environmental toxicology and pharmacology, 31(1), 220-232 (2011-07-27)
The evaluation of the mutagenic and antimutagenic actions of extracts obtained from aerial part of Teucrium ramosissimum was assayed using the Salmonella typhimurium assay system. The effect of the same extracts on genotoxicity and SOS response induced by aflatoxin B(1)
Amitabha Chakrabarti et al.
The Journal of biological chemistry, 287(28), 23635-23643 (2012-05-25)
Despite advances in oncology drug development, most commonly used cancer therapeutics exhibit serious adverse effects. Often the toxicities of chemotherapeutics are due to the induction of significant DNA damage that is necessary for their ability to kill cancer cells. In
Tomohiro Nishimura et al.
Drug metabolism and pharmacokinetics, 27(4), 439-446 (2012-02-23)
The purpose of this study was to clarify the transport characteristics of nucleosides in rat placenta and the changes of functional expression of nucleoside transporters in rat placenta with experimental diabetes mellitus. Placental uptake clearances of [(3)H]adenosine and [(3)H]zidovudine from
Sumit Parmar et al.
Pharmacogenomics, 12(4), 503-514 (2011-04-28)
To adopt an individualized approach to assess cytarabine (ara-C) hematotoxicity, we studied the relationship between pharmacogenetic variability in the cytidine deaminase gene (CDA) and ara-C toxicity in native peripheral blood mononuclear cells from 100 healthy volunteers. Peripheral blood mononuclear cells
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