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Merck

DRD4

dopamine receptor D4

Sinónimos:
D4DR
Especie:
Human DRD4 (1815), Mouse Drd4 (13491), Rat Drd4 (25432), naked mole-rat Drd4 (101708437), dog DRD4 (448805), domestic guinea pig Drd4 (100733356), dog DRD4 (607223), chicken DRD4 (423016)
ID UniProtKB:
P21917, B0M0J7, Q7Z7Q5, Q8NGM5
ID del gen:
  • Human(1815) Summary: This gene encodes the D4 subtype of the dopamine receptor. The D4 subtype is a G-protein coupled receptor which inhibits adenylyl cyclase. It is a target for drugs which treat schizophrenia and Parkinson disease. Mutations in this gene have been associated with various behavioral phenotypes, including autonomic nervous system dysfunction, attention deficit/hyperactivity disorder, and the personality trait of novelty seeking. This gene contains a polymorphic number (2-10 copies) of tandem 48 nt repeats; the sequence shown contains four repeats. [provided by RefSeq, Jul 2008]
  • Mouse(13491) dopamine receptor D4
  • Rat(25432) dopamine receptor D4
  • naked mole-rat(101708437) dopamine receptor D4
  • dog(448805) dopamine receptor D4
  • domestic guinea pig(100733356) dopamine receptor D4
  • dog(607223) dopamine receptor D4
  • chicken(423016) dopamine receptor D4

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Small Molecule - Agonist

Referencia del producto
Descripción
Especie
Y0002019
Ropinirole for peak identification 3, European Pharmacopoeia (EP) Reference Standard,
Especie
human
594687
α-Sexithiophene, ,
Especie
human, rat

Small Molecule - Antagonist

Referencia del producto
Descripción
Especie
L131
L-745,870 hydrochloride, ,
Especie
human
U115
U-101958 maleate salt, solid,
Especie
human
L135
L-741,626, ≥98% (HPLC),
Especie
human
B9308
BP897, >98% (HPLC), solid,
Especie
human, rat
D122
Domperidone, powder, ≥98% (HPLC),
Especie
human, rat

Antibodies

Referencia del producto
Descripción
Reactividad de especies
Aplicación
HPA062682
Anti-Drd4 Antibody Produced In Rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reactividad de especies
human
Aplicación
immunofluorescence
MABN125
Anti-DRD4 Antibody, clone 2B9, clone 2B9, from mouse,
Reactividad de especies
human, mouse, rat
Aplicación
immunocytochemistry
western blot
AB1787P
Anti-Dopamine D4 Receptor Antibody, extracellular domain, Chemicon®, from rabbit,
Reactividad de especies
mouse
Aplicación
ELISA
western blot
324405
Anti-Dopamine D₄ Receptor Rabbit pAb, lyophilized, Calbiochem®,
Reactividad de especies
human, rat
Aplicación

Small Molecule - Inhibitor

Referencia del producto
Descripción
Especie
594687
α-Sexithiophene, ,
Especie
human, rat
51330
Harmaline, ≥95%,
Especie
human, rat

Small Molecule - Metabolite

Referencia del producto
Descripción
Especie
H3132
3-Hydroxy-4-methoxyphenethylamine hydrochloride, ,
Especie
human
M4251
3-Methoxytyramine hydrochloride, ≥95.5%, crystalline,
Especie
human

Small Molecule - Mixed Agonist/Antagonist

Referencia del producto
Descripción
Especie
B9308
BP897, >98% (HPLC), solid,
Especie
human, rat

Small Molecule - Precursor

Referencia del producto
Descripción
Especie
D9628
3,4-Dihidroxi-L-fenilalanina, ≥98% (TLC),
Especie
mouse, human, rat
D9503
3,4-Dihydroxy-DL-phenylalanine, ,
Especie
mouse, human, rat

esiRNA

Referencia del producto
Descripción
Especie
EMU028911
MISSION® esiRNA, targeting mouse Drd4,
Especie
mouse