D122

Domperidone

≥98% (HPLC), Dopamine D2 receptor antagonist, powder

• Sinónimos: 4-(5-Chloro-2-oxo-1-benzimidazolinyl)-1-[3-(2-oxobenzimidazolinyl)propyl]piperidine
• Fórmula empírica (notación de Hill): C₂₂H₂₄ClN₅O₂
• Número CAS: 57808-66-9
• Peso molecular: 425.91
• NACRES: NA.77
• PubChem Substance ID: 24277911
• UNSPSC Code: 12352200
• EC Number: 260-968-7
• MDL number: MFCD00069256
• Assay: ≥98% (HPLC)
• Form: powder

Propiedades

• Nombre del producto: Domperidone, powder, ≥98% (HPLC)
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white
• solubility: DMSO: >10 mg/mL, 0.1 M HCl: soluble, 0.1 M NaOH: slightly soluble, H₂O: insoluble
• originator: Johnson & Johnson
• SMILES string: Clc1ccc2N(C3CCN(CCCN4C(=O)Nc5ccccc45)CC3)C(=O)Nc2c1
• InChI: 1S/C22H24ClN5O2/c23-15-6-7-20-18(14-15)25-22(30)28(20)16-8-12-26(13-9-16)10-3-11-27-19-5-2-1-4-17(19)24-21(27)29/h1-2,4-7,14,16H,3,8-13H2,(H,24,29)(H,25,30)
• InChI key: FGXWKSZFVQUSTL-UHFFFAOYSA-N
• Gene Information: human ... DRD1(1812), DRD2(1813), DRD3(1814), DRD4(1815), DRD5(1816), KCNH2(3757) ; rat ... Drd1a(24316), Drd2(24318), Drd3(29238), Htr3a(79246)

Descripción

Biochem/physiol Actions

Peripheral dopamine receptor antagonist that does not cross the blood-brain barrier; anti-emetic.

Features and Benefits

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Información de seguridad

• pictograms: GHS08
• signalword: Warning
• hcodes: H361fd
• pcodes: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Hazard Classifications: Repr. 2
• Clase de almacenamiento: 11 - Combustible Solids
• wgk: WGK 3
• ppe: Eyeshields, Gloves, type P3 (EN 143) respirator cartridges