ABCB1
ATP-binding cassette, sub-family B (MDR/TAP), member 1
Sinónimos:
ABC20, CD243, CLCS, GP170, MDR1, P-GP, PGY1
Especie:
Human ABCB1 (5243), dog ABCB1 (403879), domestic cat ABCB1 (493707), Thale Cress ABCB1 (818265), naked mole-rat Abcb1 (101702843), domestic guinea pig Abcb1 (100733532), Domestic Rabbit ABCB1 (100008914), sheep ABCB1 (443367), Horse ABCB1 (100034074), cow ABCB1 (281585)
ID UniProtKB:
ID del gen:
- Human(5243) Summary: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. [provided by RefSeq, Jul 2008]
- dog(403879) ATP-binding cassette, sub-family B (MDR/TAP), member 1
- domestic cat(493707) ATP-binding cassette, sub-family B (MDR/TAP), member 1
- Thale Cress(818265) ABC transporter B family member 1
- naked mole-rat(101702843) ATP-binding cassette, sub-family B (MDR/TAP), member 1
- domestic guinea pig(100733532) ATP-binding cassette, sub-family B (MDR/TAP), member 1
- Domestic Rabbit(100008914) ATP-binding cassette, sub-family B (MDR/TAP), member 1
- sheep(443367) ATP-binding cassette, sub-family B (MDR/TAP), member 1
- Horse(100034074) ATP-binding cassette, sub-family B (MDR/TAP), member 1
- cow(281585) ATP-binding cassette, sub-family B (MDR/TAP), member 1
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Small Molecule - Agonist
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Hydrocortisone solution, 50 μM, sterile-filtered, BioXtra, suitable for cell culture,
Especie
human, mouse, rat
Hydrocortisone, γ-irradiated, powder, BioXtra, suitable for cell culture,
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Small Molecule - Antagonist
Antibodies
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Aplicación
Anti-MDR1 Antibody, clone JSB-1, culture supernatant, clone JSB-1, Chemicon®,
Reactividad de especies
hamster, human
Aplicación
flow cytometry
immunocytochemistry
immunohistochemistry
western blot
immunocytochemistry
immunohistochemistry
western blot
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Reactividad de especies
human
Aplicación
flow cytometry
immunohistochemistry
immunohistochemistry
Anti-MDR1 Antibody, conformational extracellular epitope, clone UIC2, clone UIC2, Chemicon®, from mouse,
Reactividad de especies
human, primate
Aplicación
flow cytometry
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immunofluorescence
immunohistochemistry
immunoprecipitation (IP)
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human, rat
Aplicación
immunohistochemistry
western blot
western blot
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Reactividad de especies
human, primate
Aplicación
flow cytometry
immunofluorescence
immunohistochemistry
immunoprecipitation (IP)
immunofluorescence
immunohistochemistry
immunoprecipitation (IP)
Kits
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Especie
Small Molecule - Mixed Agonist/Antagonist
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mouse, rat, human
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mouse, human, rat
esiRNA
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