SML2948
Mca-APK(Dnp)-OH trifluoroacetate
≥97% (HPLC)
Synonym(s):
Mca-APK(Dnp) TFA salt (Mca = 7-Methoxycoumarin-4-yl; Dnp = 2,4-dinitrophenyl), Mca-Ala-Pro-Lys(Dnp) TFA salt, Mca-Ala-Pro-Lys(Dnp)-OH TFA salt
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1 MG
$194.00
5 MG
$776.00
About This Item
Empirical Formula (Hill Notation):
C32H36N6O12 · xC2HF3O2
Molecular Weight:
696.66 (free base basis)
UNSPSC Code:
12352200
NACRES:
NA.77
Recommended Products
Quality Level
Assay
≥97% (HPLC)
form
film or powder
storage condition
desiccated
color
white to dark beige
storage temp.
−20°C
Biochem/physiol Actions
Mca-APK(Dnp)-OH is a widely used fluorescent substrate for angiotensin-converting enzyme 2 (ACE2 cleaves between P & K). Proteolytic cleavage separates 7-methoxycoumarin-4-acetyl (Mca) from the fluorescence-quenching group 2,4-dinitrophenyl (Dnp), resulting in increased Mca fluorescence (Ex: 320-328 nm, Em: 405-420 nm). The fluorescence increase over background upon Mca-APK(Dnp) cleavage is more than 14-fold higher than that of Mca-YVADAPK(Dnp), while only Mca-YVADAPK(Dnp), but not Mca-APK(Dnp), can also be used for assessing caspase-1 (ICE) activity.
Popular fluorescent substrate for angiotensin-converting enzyme 2 (ACE2).
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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Chintan K Gandhi et al.
Lung, 197(2), 227-233 (2019-02-14)
Pancreatic digestive enzymes present in meconium might be responsible for meconium-induced lung injury. The local Renin Angiotensin System plays an important role in lung injury and inflammation. Particularly, angiotensin converting enzyme-2 (ACE-2) has been identified as a protective lung enzyme against
Jan Wysocki et al.
Biomolecules, 9(12) (2019-12-22)
ACE2 is a monocarboxypeptidase which generates Angiotensin (1-7) from Angiotensin II (1-8). Attempts to target the kidney Renin Angiotensin System using native ACE2 to treat kidney disease are hampered by its large molecular size, 100 kDa, which precludes its glomerular
Danielle Stoll et al.
Physiological reports, 7(11), e14105-e14105 (2019-06-06)
The kidney is an important target of the renin-ANG-aldosterone system (RAAS). To date, several studies have demonstrated the existence of a local RAAS in various tissues, including the renal tissue. The mineralocorticoid aldosterone is known to play a critical role
Aline Maria Arlindo De Souza et al.
Physiological reports, 8(1), e14338-e14338 (2020-01-12)
We previously showed that 2 weeks of a severe food restricted (sFR) diet (40% of the caloric intake of the control (CT) diet) up-regulated the circulating renin angiotensin (Ang) system (RAS) in female Fischer rats, most likely as a result of
Xiaomiao Zhang et al.
Archives of biochemistry and biophysics, 672, 108061-108061 (2019-07-30)
Autophagy exerts a dual role in promoting cell death or survival. Recent studies have shown that it may play an important role in lipopolysaccharide (LPS)-induced acute lung injury (ALI). It was also suggested that angiotensin converting enzyme 2 (ACE2) may
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