G1171

Gö 6976

≥98% (HPLC), powder

• Synonym(s): 12-(2-Cyanoethyl)-6,7,12,13-tetrahydro-13-methyl-5-oxo-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole, Go 6976
• Empirical Formula (Hill Notation): C₂₄H₁₈N₄O
• CAS Number: 136194-77-9
• Molecular Weight: 378.43
• MDL number: MFCD00236434
• UNSPSC Code: 12352200
• PubChem Substance ID: 329799832

Properties

• Assay: ≥98% (HPLC)
• form: powder
• color: white
• solubility: DMSO: >5 mg/mL
• storage temp.: −20°C
• SMILES string: Cn1c2ccccc2c3c4C(=O)NCc4c5c6ccccc6n(CCC#N)c5c13
• InChI: 1S/C24H18N4O/c1-27-17-9-4-2-7-14(17)20-21-16(13-26-24(21)29)19-15-8-3-5-10-18(15)28(12-6-11-25)23(19)22(20)27/h2-5,7-10H,6,12-13H2,1H3,(H,26,29)
• InChI key: VWVYILCFSYNJHF-UHFFFAOYSA-N

Description

Application

Gö 6976 has been used:

• as an inhibitor of protein kinase C (PKC) in mammalian cell lines
• as a PKCμ inhibitor in oocytes
• as a PKC-α to test its effect on phosphorylation of protein kinase-B (Akt) and extracellular-signal-regulated kinase (ERK) levels

Biochem/physiol Actions

Go¨6976 also acts as an effective inhibitor of protein kinase C isoform (PKCμ) and abolishes phorbol ester mediated potentiation in oocytes. It inhibits PKC α and β selectively. Go-6976 may also inhibit S6-kinase 1.

Gö 6976 is an inhibitor of protein kinase C (PKC) specific for α (IC₅₀=2.3 nM) and β1 (IC₅₀=6.2 nM) isozymes.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves