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14300

Sigma-Aldrich

Betaine monohydrate

≥99.0% (NT)

Synonym(s):

1-carboxy-n,n,n-trimethylmethanaminium hydroxide, 2-(trimethylammonio)acetate hydrate, glycine betaine hydrate

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About This Item

Linear Formula:
(CH3)3N+CH2COO- · H2O
CAS Number:
590-47-6
Molecular Weight:
135.16
Beilstein:
3626258
EC Number:
203-490-6
MDL number:
MFCD00150010
UNSPSC Code:
51171529
PubChem Substance ID:
57647146
NACRES:
NA.25

Assay

≥99.0% (NT)

form

solid

solubility

H2O: 0.1 g/mL, clear, colorless

storage temp.

2-8°C

SMILES string

O.C[N+](C)(C)CC([O-])=O

InChI

1S/C5H11NO2.H2O/c1-6(2,3)4-5(7)8;/h4H2,1-3H3;1H2

InChI key

NJZRLXNBGZBREL-UHFFFAOYSA-N

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Application

Betaine monohydrate:

  • is suitable for use to improve the PCR amplification of GC-rich DNA sequences by reducing the formation of secondary structure caused by GC-rich regions
  • is suitable for use as a component of PCR reaction mixture
  • is suitable for use in a study to identify yield enhancers of PCR
  • has been used to study nitrogen balance and nutrient digestibility in piglets fed diets deficient in methionine and low in compatible osmolytes
  • has also been used to compare the effects of pressure on three layered hydrates

Biochem/physiol Actions

End-product of oxidative metabolism of choline, betaine is a general methyl donor, in particular in a minor pathway of methionine biosynthesis. It is used to treat homocystinuria, which is a defect in the major pathway of methionine biosynthesis.

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Theodore Spilker et al.
Journal of clinical microbiology, 50(9), 3010-3015 (2012-07-13)
The genus Achromobacter currently is comprised of seven species, including Achromobacter xylosoxidans, an opportunistic and nosocomial pathogen that displays broad-spectrum antimicrobial resistance and is recognized as causing chronic respiratory tract infection in persons with cystic fibrosis (CF). To enable strain
M Kovárová et al.
Nucleic acids research, 28(13), E70-E70 (2000-06-28)
Tetramethylammonium (TMA) chloride, dimethyl sulfoxide and formamide are known to increase, under certain conditions, the specificity and efficiency of the polymerase chain reaction (PCR). We compared the ability of several TMA derivatives and some other reagents to increase the specificity
Cletus Nunes et al.
Journal of pharmaceutical sciences, 93(1), 38-47 (2003-12-04)
The objectives were (1). to perform solid-state characterization of anhydrous betaine (A) and betaine monohydrate (M), (2). to develop a pressure differential scanning calorimetric (DSC) technique for the quantification of M when present as a minor component in a mixture
Russell D L Johnstone et al.
Acta crystallographica. Section B, Structural science, 65(Pt 6), 731-748 (2009-11-20)
We report the effect of pressure on the crystal structures of betaine monohydrate (BTM), L-cysteic acid monohydrate (CAM) and S-4-sulfo-L-phenylalanine monohydrate (SPM). All three structures are composed of layers of zwitterionic molecules separated by layers of water molecules. In BTM
Meike Eklund et al.
Archives of animal nutrition, 60(4), 289-300 (2006-08-23)
A balance experiment was carried out to investigate the effects of betaine monohydrate (BET) or betaine derived from condensed molasses solubles (CMS) as a substitute for methionine and choline on nitrogen (N) balance and total tract nutrient digestibility in weaned
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