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78973

Sigma-Aldrich

Poloxamer 188, micronized

Synonym(s):

Poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol), Lμtrol micro 68

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About This Item

CAS Number:
9003-11-6
MDL number:
MFCD00082049
UNSPSC Code:
12161900
NACRES:
NA.25

form

powder

Quality Level

100

mol wt

~7680-9510 g/mol

composition

oxyethylene content, 79.9-83.7%

technique(s)

DNA extraction: suitable
DNA purification: suitable
NMR: suitable
RNA extraction: suitable
RNA purification: suitable

impurities

organic volatile impurities, complies (meets USP requirements)
≤0.4% total ash
≤0.75% water
≤1 ppm ethylene oxide
≤20 ppm heavy metals
≤5 ppm 1,4-dioxane
≤5 ppm propylene oxide
50-125 ppm butylhydroxytoluene

color

APHA: ≤100

particle size distribution

, coeff var ≤10% (residue, No. 140 USS)
, coeff var ≤50% (residue, No 270 USS)

pH

5.0-7.5 (2.5% in H2O)

suitability

complies for Infrared spectrum

InChI

1S/C3H6O.C2H4O/c1-3-2-4-3;1-2-3-1/h3H,2H2,1H3;1-2H2

InChI key

RVGRUAULSDPKGF-UHFFFAOYSA-N

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Other Notes

The Poloxamer 188 grades are poloxamers from the extensive line of Pluronic® block copolymers.
average molecular weight/mass 7680-9510 g/mol

Legal Information

Pluronic is a registered trademark of BASF

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Certificates of Analysis (COA)

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Colloids and surfaces. B, Biointerfaces, 99, 27-37 (2011-10-18)
Polyplex particles formed with plasmid DNA (pDNA) and Pluronic P85-block-poly{N-[N-(2-aminoethyl)-2-aminoethyl]aspartamide} (P85-b-P[Asp(DET)]) demonstrated highly effective transfection ability compared to PEG-based block cationomer, PEG-b-P[Asp(DET)]. Ternary polyplexes comprising PEG-b-P[Asp(DET)], poly(ethylene oxide)-b-poly(propylene oxide)-b-poly(ethylene oxide)-b-P[Asp(DET)] (P(EPE)-b-P[Asp(DET)]) used as an analog of P85-b-P[Asp(DET)], and pDNA were
Xijun Zhang et al.
Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban, 31(6), 842-845 (2011-12-17)
This study examined the effect of P85 (a pluronic block copolymer) and microbubble (MB) ultrasound contrast agents under ultrasound irradiation on gene transfection and expression. The pEGFP plasmids that can encode enhanced green fluorescent protein (pEGFP) served as a report
Houjian Gong et al.
Langmuir : the ACS journal of surfaces and colloids, 28(38), 13590-13600 (2012-09-08)
The block polyethers PEO-PPO-ph-PPO-PEO (BPE) and PPO-PEO-ph-PEO-PPO (BEP) are synthesized by anionic polymerization using bisphenol A as initiator. Compared with Pluronic P123, the aggregation behaviors of BPE and BEP at an air/water interface are investigated by the surface tension and
Jun Song et al.
Water science and technology : a journal of the International Association on Water Pollution Research, 66(4), 792-798 (2012-07-07)
A novel method for the determination of nickel was established by ultrasonic-assisted cloud point extraction (UA-CPE) prior to flame atomic absorption spectrometry (FAAS) analysis. The nickel reacted with N,N'-bis(salicylidene)-1,2-ethanediamine (BSE) to form hydrophobic chelates, which were extracted into the micelles
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