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QBD10553

Sigma-Aldrich

MAL-dPEG®12-TFP ester

Synonym(s):

Polyethylene glycol

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About This Item

Empirical Formula (Hill Notation):
C40H60F4N2O17
Molecular Weight:
916.90
MDL number:
UNSPSC Code:
12352108
PubChem Substance ID:
NACRES:
NA.22

Pricing and availability is not currently available.

Assay

>90%

form

solid or viscous liquid

reaction suitability

reactivity: thiol reactive
reagent type: cross-linking reagent
reactivity: amine reactive

polymer architecture

shape: linear
functionality: heterobifunctional

shipped in

ambient

storage temp.

−20°C

SMILES string

O=C(CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(CCN1C(C=CC1=O)=O)=O)OC2=C(C(F)=CC(F)=C2F)F

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This Item
QBD10554QBD11303QBD10555
assay

>90%

assay

>90%

assay

>90%

assay

>90%

polymer architecture

shape: linear
functionality: heterobifunctional

polymer architecture

shape: linear
functionality: heterobifunctional

polymer architecture

shape: linear
functionality: heterobifunctional

polymer architecture

shape: linear
functionality: heterobifunctional

reaction suitability

reactivity: thiol reactive, reagent type: cross-linking reagent
reactivity: amine reactive

reaction suitability

reactivity: thiol reactive, reagent type: cross-linking reagent
reactivity: amine reactive

reaction suitability

reactivity: thiol reactive, reagent type: cross-linking reagent
reactivity: amine reactive

reaction suitability

reactivity: thiol reactive, reagent type: cross-linking reagent
reactivity: amine reactive

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

shipped in

ambient

shipped in

ambient

shipped in

ambient

shipped in

ambient

Features and Benefits

MAL-dPEG®12-TFP ester is a heterobifunctional, linear crosslinking reagent containing a maleimide group on one end of the single molecular weight dPEG® spacer arm and an amine-reactive active ester on the other end. The maleimide group reacts readily and specifically with free sulfhydryl groups in aqueous media at pH 6.5-7.5. 2,3,5,6-tetrafluorophenyl (TFP) ester ester is used widely in reactions with primary amines. The TFP-amine reactions can be carried out in aqueous or organic solvent. The dPEG® spacer is hydrophilic and non-immunogenic. Because it is a single molecular weight product, it gives the user precise spatial control. The dPEG® spacer also improves water solubility, decreases immunogenicity, and increases the hydrodynamic volume of the conjugate. The increased hydrodynamic volume results in longer serum half-life in vivo.

Legal Information

Products Protected under U.S. Patents # 7,888,536 B2
dPEG is a registered trademark of Quanta BioDesign

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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