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Merck

302295

Sigma-Aldrich

5-Nitro-2-thiophenecarboxaldehyde

98%

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About This Item

Empirical Formula (Hill Notation):
C5H3NO3S
CAS Number:
Molecular Weight:
157.15
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22

Pricing and availability is not currently available.

Assay

98%

form

solid

mp

75-77 °C (lit.)

solubility

acetone: soluble 1%, clear, yellow

functional group

aldehyde
nitro

SMILES string

[H]C(=O)c1ccc(s1)[N+]([O-])=O

InChI

1S/C5H3NO3S/c7-3-4-1-2-5(10-4)6(8)9/h1-3H

InChI key

CHTSWZNXEKOLPM-UHFFFAOYSA-N

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1 of 4

This Item
429880139033408026
solubility

acetone: soluble 1%, clear, yellow

solubility

-

solubility

-

solubility

-

mp

75-77 °C (lit.)

mp

115-117 °C (lit.)

mp

75-77 °C (lit.)

mp

95-97 °C (lit.)

form

solid

form

-

form

-

form

-

General description

Diastereoselectivity in [4+2] cycloaddition of 1-methoxy-2-methyl-3-(trimethylsiloxy)-1,3-pentadiene with 5-nitro-2-thiophenecarboxaldehyde was investigated.[1]

Application

5-Nitro-2-thiophenecarboxaldehyde was used in preparation of 2, 3-dihydro-2-(5-nitro-2-thienyl) quinazolin-4-(1H)-ones[2] and various novel oxime ether derivatives, anti-protozoan agents.[3]

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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A series of new 2-(phenylthio) benzoylarylhydrazones were synthesized by acid-catalyzed condensation of hydrazide 3 with corresponding aldehydes. The chemical structures of the compounds were elucidated by FT-IR, (1)H-NMR and Mass spectra. All newly synthesized compounds were evaluated for their antimycobacterial
Antibacterial 2,3-dihydro-2-(5-nitro-2-thienyl)-quinazolin-4(1H)-ones.
R J Alaimo et al.
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Proceedings of the National Academy of Sciences of the United States of America, 101(15), 5391-5395 (2004-04-03)
Chiral dirhodium(II) carboxamidates are highly efficient catalysts for reactions between a variety of aldehydes and activated dienes. Catalyst loadings as low at 0.01 mol % have been realized with enantioselectivities up to 97%. Kinetic investigations reveal a pronounced electronic influence
Synthesis and< i> in vitro</i> anti-protozoan activity of new 5-nitrothiophene oxime ether derivatives.
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European Journal of Medicinal Chemistry, 28(1), 23-27 (1993)
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