Yes, FITC-Dextran is frequently used for the study of migration, transport and perfusion in animals models. FITC-Dextran is readily detected in formalin-fixed samples. See the link below for a publication that may be helpful:
https://www.cell.com/cell-reports/pdf/S2211-1247(21)00510-6.pdf
90718
Fluorescein isothiocyanate–dextran
average Mw 70,000
Synonym(s):
FITC–Dextran 70, FITC–Dextran
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About This Item
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biological source
synthetic
Quality Level
conjugate
FITC conjugate
form
powder or crystals
mol wt
average Mw 70,000
extent of labeling
0.001-0.020 mol/mol FITC glucose
fluorescence
λex 493 nm; λem 520 nm±5 nm in 0.1 M Tris pH 8.0
application(s)
cell analysis
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General description
Fluorescein isothiocyanate–dextran is an anionic fluorescent probe. The carboxyl group provides the negative charge, which improves the overall permeability of the molecule. It is supplied as a yellow powder that is freely soluble in water and electrolyte solutions. Fluorescein isothiocyanate–dextran is insoluble in most organic samples such as ethanol, methanol, acetone, and chloroform., however, it dissolves in DMSO, formamide, and a few other polar organic solvents.
Application
Dextran labeled with fluorescein isothiocyanate for possible use in perfusion studies in animals.
Fluorescein isothiocyanate–dextran has an application of cell analysis, Dextran labeled with fluorescein isothiocyanate for possible use in perfusion studies in animals. FITC-dextrans are primary source of studying permeability and transport in cells and tissues and can also be a tool for permeability studies of other materials.
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Target Organs
Respiratory system
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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Is this FITC-Dextran compatible with formaldehyde fixation in animal tissues?
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