481975

(--)-Nicotine, Ditartrate

Potent agonist of the nicotinic acetylcholine receptor.

• Synonym(s): (--)-Nicotine, Ditartrate, (S)-3-(1-Methyl-2-pyrrolindinyl)pyridine, Di- d-tartrate, (S)-3-(1-Methyl-2-pyrrolindinyl)pyridine, Di-d-tartrate
• Empirical Formula (Hill Notation): C₁₀H₁₄N₂ · 2C₄H₆O₆
• CAS Number: 65-31-6
• Molecular Weight: 462.41
• MDL number: MFCD00069368
• UNSPSC Code: 12352210
• NACRES: NA.77

Properties

• description: Merck USA index - 14, 6524
• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze
• color: white to off-white
• solubility: ethanol: 10 mg/mL; water: 10 mg/mL
• shipped in: ambient
• storage temp.: 10-30°C
• SMILES string: N1(C(CCC1)c2cnccc2)C.O[C@H]([C@@H](O)C(=O)O)C(=O)O.O[C@H]([C@@H](O)C(=O)O)C(=O)O
• InChI: 1S/C10H14N2.2C4H6O6/c1-12-7-3-5-10(12)9-4-2-6-11-8-9;2*5-1(3(7)8)2(6)4(9)10/h2,4,6,8,10H,3,5,7H2,1H3;2*1-2,5-6H,(H,7,8)(H,9,10)/t;2*1-,2-/m.11/s1
• InChI key: RFEJUZJILGIRHQ-WBPXWQEISA-N

Description

General description

Potent agonist of the nicotinic acetylcholine receptor. Stimulates autonomic ganglia and skeletal muscle neuromuscular junctions.

Biochem/physiol Actions

Cell permeable: no

Primary Target
Nicotinic acetylcholine receptor

Product does not compete with ATP.

Reversible: no

Warning

Toxicity: Highly Toxic (H)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C) for long-term storage or refrigerate (4°C) for short-term storage. Stock solutions are stable for up to 2 weeks at 4°C or for up to 6 months at -20°C.

Other Notes

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Rand, M.J. 1989. Prog. Brain Res. 79, 3.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Pictograms: GHS06,GHS08,GHS09
• Signal Word: Danger
• Hazard Statements: H301,H319,H330,H361d,H411
• Precautionary Statements: P202 - P260 - P264 - P273 - P304 + P340 + P310 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 2 Inhalation - Acute Tox. 3 Oral - Aquatic Chronic 2 - Eye Irrit. 2 - Repr. 2
• Storage Class Code: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 2
• Flash Point(F): 289.8 °F
• Flash Point(C): 143.2 °C