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78973

Sigma-Aldrich

Poloxamer 188, micronized

Synonym(s):

Poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol), Lμtrol micro 68

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About This Item

CAS Number:
9003-11-6
MDL number:
MFCD00082049
UNSPSC Code:
12161900
NACRES:
NA.25

form

powder

Quality Level

100

mol wt

~7680-9510 g/mol

composition

oxyethylene content, 79.9-83.7%

technique(s)

DNA extraction: suitable
DNA purification: suitable
NMR: suitable
RNA extraction: suitable
RNA purification: suitable

impurities

organic volatile impurities, complies (meets USP requirements)
≤0.4% total ash
≤0.75% water
≤1 ppm ethylene oxide
≤20 ppm heavy metals
≤5 ppm 1,4-dioxane
≤5 ppm propylene oxide
50-125 ppm butylhydroxytoluene

color

APHA: ≤100

particle size distribution

, coeff var ≤10% (residue, No. 140 USS)
, coeff var ≤50% (residue, No 270 USS)

pH

5.0-7.5 (2.5% in H2O)

suitability

complies for Infrared spectrum

SMILES string

O2C(C2)C.O1CC1

InChI

1S/C3H6O.C2H4O/c1-3-2-4-3;1-2-3-1/h3H,2H2,1H3;1-2H2

InChI key

RVGRUAULSDPKGF-UHFFFAOYSA-N

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Other Notes

The Poloxamer 188 grades are poloxamers from the extensive line of Pluronic® block copolymers.
average molecular weight/mass 7680-9510 g/mol

Legal Information

Pluronic is a registered trademark of BASF

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

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Certificates of Analysis (COA)

Lot/Batch Number
BCCK1944
BCCF6791
BCCB9442
BCBW8463
BCBT6082

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Liyan Zhao et al.
Colloids and surfaces. B, Biointerfaces, 97, 101-108 (2012-05-23)
In this study, curcumin (Cur) loaded mixed micelles (Cur-PF), composed of Pluronic P123 (P123) and Pluronic F68 (F68), was prepared using the thin-film hydration method and evaluated in vitro. The preparation process was optimized with a central composite design (CCD).
V K Zhalimov et al.
Biofizika, 57(2), 308-316 (2012-05-19)
It has been shown that sorption of most proteins with the molecular weight lower than 200 kDa from human blood plasma on the surface of perfluorocarbon emulsion, stabilized with proxanol 268, is mainly based on hydrophobic interaction, whereas sorption of
Yanbin Guan et al.
Archives of pharmacal research, 34(10), 1719-1728 (2011-11-15)
The aim of the present study was to evaluate the effect of pluronic P123 (P123) and pluronic F127 (F127) on intestinal P-glycoprotein (P-gp) and cytochrome P450 3A using the specific substrates rhodamine-123 (R-123) and midazolam, respectively. Caco-2 cells and everted
Neeta Jain-Gupta et al.
FEMS immunology and medical microbiology, 66(3), 436-444 (2012-11-21)
Brucellosis is the most common zoonotic disease worldwide, and there is no vaccine for human use. Brucella melitensis Rev1, a live attenuated strain, is the commercial vaccine for small ruminants to prevent B. melitensis infections but has been associated with abortions
Wanhua Feng et al.
Colloids and surfaces. B, Biointerfaces, 105, 43-50 (2013-01-29)
The interaction between bacteria and surfaces is central to many environmental, industrial and medical applications. Surfactants are commonly used in these applications and can potentially influence the bacterium/surface interaction. The effect of surfactants upon bacterial cell surface thermodynamic properties was
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