N-methyl-d-aspartate receptor (NMDAR1) is a subtype of the ionotropic glutamate receptors (iGluRs). It is coded by GRIN1 gene. It is located on human chromosome 9q34.3. NMDAR1is expressed in epidermal melanocytes.
Anti-NMDAR1 antibody detects endogenous levels of total NMDAR1 protein.
Immunogen
The antiserum was produced against synthesized peptide derived from human NMDAR1.
Immunogen Range: 856-905
Application
Anti-NMDAR1, C-Terminal antibody has been used in western blot analysis.
Biochem/physiol Actions
N-methyl-d-aspartate receptor (NMDAR1) plays an important role in the pathophysiology of schizophrenia, bipolar disorder and depression. Mutations in GRIN1 gene results in severe intellectual disability, hypotonia, hyperkinetic and stereotyped movements, and epilepsy.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
American journal of physiology. Cell physiology, 313(2), C187-C196 (2017-06-02)
Major depression is an important clinical factor in ventricular arrhythmia. Patients diagnosed with major depression overexpress N-methyl-d-aspartate receptors (NMDARs). Previous studies found that chronic NMDAR activation increases susceptibility to ventricular arrhythmias. We aimed to explore the mechanisms by which NMDAR
De novo GRIN1 mutations: An emerging cause of severe early infantile encephalopathy
Zehavi Y, et al.
European Journal of Medical Genetics, 60(6), 317-320 (2017)
Evidence that the N-methyl-D-aspartate subunit 1 receptor gene (GRIN1) confers susceptibility to bipolar disorder
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