R3250 is classified as a matrix dispersion. This product contains gelatin, sugar, modified food starch, and other components to make it convenient as an "oil dispersible material," which will not dissolve in chloroform. The gelatin and starch components in this product would not be soluble but will be dispersed or suspended in the oil. For a soluble retinol acetate product, recommended Product No. is R4632, Retinol Acetate all trans, which is soluble in chloroform (50 mg/ml), yielding a clear, yellow-green solution. Product No. R4632 is also soluble in ethanol.
R3250
Retinyl acetate
synthetic, matrix dispersion, 475,000-650,000 USP units/g
Synonym(s):
Retinol acetate, Vitamin A acetate
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All Photos(2)
About This Item
Empirical Formula (Hill Notation):
C22H32O2
CAS Number:
Molecular Weight:
328.49
Beilstein:
1915439
EC Number:
MDL number:
UNSPSC Code:
12352205
eCl@ss:
34058009
PubChem Substance ID:
NACRES:
NA.79
Pricing and availability is not currently available.
Recommended Products
biological source
synthetic
Quality Level
form
matrix dispersion
specific activity
475,000-650,000 USP units/g
color
yellow
mp
57-58 °C
storage temp.
−20°C
SMILES string
CC1=C(/C=C/C(C)=C/C=C/C(C)=C/COC(C)=O)C(C)(C)CCC1
InChI
1S/C22H32O2/c1-17(9-7-10-18(2)14-16-24-20(4)23)12-13-21-19(3)11-8-15-22(21,5)6/h7,9-10,12-14H,8,11,15-16H2,1-6H3/b10-7+,13-12+,17-9+,18-14+
InChI key
QGNJRVVDBSJHIZ-QHLGVNSISA-N
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General description
Retinal, retinol and retinoic acid are the aldehyde, alcohol and acid forms of vitamin A. The retinoids exist as many geometric isomers due to the unsaturated bonds in the aliphatic chain. Retinoids also exist as retinyl esters such as retinyl propionate, retinyl acetate and retinyl palmitate.[1]
Application
Retinyl acetate has been used:
- a control diet to study its effect at different developmental periods in fish larvae[2]
- to study its inhibitory effects on Mycobacterium avium subspecies paratuberculosis (MAP) strains[3]
- as an internal standard in high performance liquid chromatography (HPLC) to quantify vitamin A in fortified milk[4]
Biochem/physiol Actions
Physical form
Dispersion in cornstarch-gelatin matrix. Oil dispersible
Analysis Note
Activity based on HPLC comparison to USP standard.
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Aquatic Chronic 4 - Repr. 1B
Storage Class Code
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Laure A N Villeneuve et al.
The British journal of nutrition, 95(4), 677-687 (2006-03-31)
The effect of the feeding period on larval development was investigated in European sea bass larvae by considering the expression level of some genes involved in morphogenesis. Larvae were fed a control diet except during three different periods (period A:
Intake of high levels of vitamin A and polyunsaturated fatty acids during different developmental periods modifies the expression of morphogenesis genes in European sea bass (Dicentrarchus labrax)
Villeneuve LAN, et al.
The British Journal of Nutrition, 95(4), 677-687 (2006)
Vitamins A & D inhibit the growth of mycobacteria in radiometric culture
Greenstein RJ, et al.
PLoS ONE, 7(1), e29631-e29631 (2012)
Effect of combined selenium and retinyl acetate treatment on mammary carcinogenesis
Thompson HJ, et al.
Cancer Research, 41(4), 1413-1416 (1981)
A survey of vitamin A and D contents of fortified fluid milk in Ontario
Faulkner H, et al.
Journal of Dairy Science, 83(6), 1210-1216 (2000)
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What is the solubility information for this product? It is not dissolved in hexane, heptane, acetone, isopropyl alcohol, water, and absolute ethanol; even left overnight on stir plate.
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