After adding meclofenamate, we have not specifically studied the impact on diminished U46619-induced vasoconstriction. However, based on a literature search, it is likely that meclofenamate could lead to diminished U46619-induced vasoconstriction as it is known to alter the binding of U46619 to thromboxane receptors.
M4531
Meclofenamic acid sodium salt
Synonym(s):
2-[(2,6-Dichloro-3-methylphenyl)amino]benzoic acid sodium salt
Sign Into View Organizational & Contract Pricing
All Photos(2)
About This Item
Linear Formula:
C14H10Cl2NO2Na
CAS Number:
Molecular Weight:
318.13
EC Number:
MDL number:
UNSPSC Code:
12352106
PubChem Substance ID:
NACRES:
NA.77
Pricing and availability is not currently available.
Recommended Products
biological source
synthetic (organic)
Quality Level
Assay
≥93% (HPLC)
form
powder
solubility
water: 50 mg/mL, clear, colorless to faintly brownish-yellow
water: 50 mg/mL, clear, colorless to faintly yellow
water: 50 mg/mL, clear, colorless to very faintly brown
SMILES string
[Na].Cc1ccc(Cl)c(Nc2ccccc2C(O)=O)c1Cl
InChI
1S/C14H11Cl2NO2.Na.H/c1-8-6-7-10(15)13(12(8)16)17-11-5-3-2-4-9(11)14(18)19;;/h2-7,17H,1H3,(H,18,19);;
InChI key
CHGIZYUDGOIAFY-UHFFFAOYSA-N
Looking for similar products? Visit Product Comparison Guide
General description
Meclofenamic acid consists of two aryl moieties that are twisted in perpendicular orientation, it includes N-2,6-dichloro-3-methylphenyl group and N-2-benzoic acid group. Because of the low aqueous solubility of the compound, it is commercially available as sodium salt.[1]
Application
Biochem/physiol Actions
Cyclooxygenase (IC50 = 0.6 μM) and 5-lipoxygenase (IC50 = 46.3 μM) inhibitor.
Meclofenamic acid (MFA) is a nonsteroidal anti-inflammatory, analgesic and antipyretic drug. It inhibits prostaglandin biosynthesis pathway and finds its application in the treatment of postoperative and traumatic inflammation and swelling. MFA functions in opening the potassium voltage-gated channel subfamily Q member 2/member 3 (KCNQ2/Q3).[1]
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Customers Also Viewed
Homeostatic plasticity shapes cell-type-specific wiring in the retina
Tien NW, et al.
Neuron, 94(3), 656-665 (2017)
Diverse inhibitory and excitatory mechanisms shape temporal tuning in transient OFF alpha ganglion cells in the rabbit retina
Murphy-Baum BL and Taylor WR
The Journal of Physiology, 596(3), 477-495 (2018)
Boctor, A.M., et al.
Prostaglandins Leukotrienes Med., 23, 229-229 (1986)
High solubility piperazine salts of the nonsteroidal anti-inflammatory drug (NSAID) meclofenamic acid
Sanphui P, et al.
Crystal Growth & Design, 12(4), 2023-2036 (2012)
Jungryul Ahn et al.
Frontiers in cellular neuroscience, 16, 889663-889663 (2022-05-24)
Retinal prostheses have shown some clinical success in patients with retinitis pigmentosa and age-related macular degeneration. However, even after the implantation of a retinal prosthesis, the patient's visual acuity is at best less than 20/420. Reduced visual acuity may be
-
Hello, a vascular lab conducts wire myography with human (pregnant) omental resistance arteries. U46619 (cat# D8174) is used to wake up the vessels, followed by a U46619 dose-response curve to calculate an EC80. When the inhibitor meclofenamate (cat# M4531) is added, the vessels exhibit a significantly reduced constriction response to U46619, preventing the testing of a vasodilator curve (e.g. bradykinin) due to low pre-constriction.
1 answer-
Helpful?
-
Active Filters
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service
