A2731

AMG 9810

≥98% (HPLC), powder

• Synonym(s): 2E-N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-3-[4-(1,1-dimethylethyl)phenyl]-2-Propenamide
• Empirical Formula (Hill Notation): C₂₁H₂₃NO₃
• CAS Number: 545395-94-6
• Molecular Weight: 337.41
• MDL number: MFCD00955103
• UNSPSC Code: 12352203
• PubChem Substance ID: 329770793
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: >5 mg/mL
• originator: Amgen
• storage temp.: 2-8°C
• SMILES string: CC(C)(C)c1ccc(\C=C\C(=O)Nc2ccc3OCCOc3c2)cc1
• InChI: 1S/C21H23NO3/c1-21(2,3)16-7-4-15(5-8-16)6-11-20(23)22-17-9-10-18-19(14-17)25-13-12-24-18/h4-11,14H,12-13H2,1-3H3,(H,22,23)/b11-6+
• InChI key: GZTFUVZVLYUPRG-IZZDOVSWSA-N

Description

Biochem/physiol Actions

AMG 9810 is the cinnamide TRPV1 (vanilloid receptor 1) antagonist, that can prevent eye wiping behavior, stimulated by capsaicin and can inverse hyperalgesia in an animal model of inflammatory pain. It possesses antihyperalgesic properties.

AMG 9810 is a potent, non-vanilloid, antagonist of the TRPV1 receptor. IC₅₀ = 17 nM.

Features and Benefits

This compound was developed by Amgen. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H302,H413
• Precautionary Statements: P264 - P270 - P273 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral - Aquatic Chronic 4
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves