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HLP501

Normal Human Intrahepatic Biliary Epithelial Cells (Cholangioctyes); passage 1

Name: Normal Human Intrahepatic Biliary Epithelial Cells (Cholangioctyes); passage 1
Brand: SIGMA

Single-Donor Cryopreserved Cholangioctyes cells isolated from human livers, high viability, and characterized by cell specific markers

Synonym(s):

Homogenous population isolated from whole human livers

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About This Item

UNSPSC Code:

41106509

NACRES:

NA.81

biological source

human liver

form

frozen liquid

packaging

pkg of 1 vial (contains ≥0.25 million cells)
pkg of 1 vial (contains ≥0.5 million cells)
pkg of 1 vial (contains ≥1 million cells)

technique(s)

cell culture | mammalian: suitable

color

cloudy

storage temp.

-140 to -196°C

General description

Lot specific orders are not able to be placed through the web. Contact your local sales rep for more details. Primary human Cholangiocytes, also known as human intrahepatic biliary epithelial cells, are epithelial cells that line the intrahepatic bile ducts. Chonlangiocytes are important for ductal bile modification and are targeted in multiple liver diseases, such as primary biliary cirrhosis, cholangiocarcinoma and sclerosing cholangitis.

Application

Human cholangiocytes are ideal in studies of: toxicity, bile production and absorption, bile duct fibrosis, hormone signaling, cholangitis, cholangiocarcinoma and more. We offer matched sets of cholangiocytes cells from same donor as Hepatocytes, which can be used for co-culture systems to better simulate the complex microenvironment of the liver and gain insights into various liver-related diseases and conditions.

Features and Benefits

Our cryopreserved human Cholangiocytes cells are derived from the human liver, with each donor providing documented consent for research use of non-transplantable organs or tissues. Following the primary culture, these cells are cryopreserved. Each lot undergoes testing for specific cell markers and comes with a guarantee of ≥ 70% post-thaw viability. In addition, all cells have been tested for the absence of HIV, HBV, HCV, Syphillis and microbial contaminants (fungi, bacteria, and mycoplasma).

Warning

Each donor is tested and found non-reactive to viral DNA from HIV-1, HIV-2, HTLV I, HTLV II, hepatitis B and hepatitis C. However, no known test can offer complete assurance that the viruses that cause HIV-1, HIV-2, HTLV I, HTLV II, hepatitis B and hepatitis C are not present. Proper precautions and biological containment should be taken when handling cells of human origin, due to their potential biohazardous nature. All human based products should be handled at a BSL-2 (Biosafety Level 2) or higher.

Disclaimer

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

Storage Class

10 - Combustible liquids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Articles

Frequently Asked Questions (FAQs) about Hepatocytes and Other Liver Cells

Explore answers to frequently asked questions (FAQs) about culturing primary human hepatocytes and other liver cells including Stellate cells, Kupffer cells, Sinusoidal Endothelial cells, and more.

Protocols

Primary Human Hepatic Kupffer Cell Culture Protocol

Discover our collection of primary human hepatic Kupffer cells and protocol for thawing, plating, and growing Kupffer cells. Find the formulation for Kupffer culture maintenance media.

Primary Human Hepatic Sinusoidal Endothelial Cells Culture Protocol

Discover our collection of primary human hepatic sinusoidal endothelial cells, a protocol for thawing, plating, and growing HHSECs, and a recipe for our HHSEC maintenance media formulation.