Anti-GPR18 antibody produced in rabbit

GPR18 (G-protein-coupled receptor 18) encodes a seven transmembrane G-protein-linked receptor that is highly expressed in testis and spleen. Its expression is strongest in hypothalamus, thyroid, peripheral blood leucocytes, cerebellum and brain stem. Its expression has been observed to a lesser extent in tissues associated with endocrine and immunologic/hematologic function. The gene is mapped to human chromosome 13q32. The open reading frame (ORF) encoded by this gene spans a length of 993bp. The encoded protein is 331 amino acids long.

N-arachidonyl glycine receptor recombinant protein epitope signature tag (PrEST)

All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry.

The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies^® protocols and other useful information.

The gene GPR18 encodes an orphan G-protein-coupled receptor that binds to N-arachidonylglycine (NAGly), an endogenous lipid that recruits BV-2 microglia and drives cellular migration. GPR18 is activated by phytocannabinoid, Δ⁹-tetrahydrocannabinol (Δ⁹-THC), and by NAGly, an oxygenated metabolite of the endogenous cannabinoid anandamide. GPR18 may be involved in central nervous system and endocannabinoid system signaling. It is found to inhibit apoptosis in melanoma metastases and it also facilitates tumor cell survival. It may serve as a potential drug target in metastatic melanoma.

Prestige Antibodies^® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies^® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:

• IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
• Protein array of 364 human recombinant protein fragments.

Corresponding Antigen APREST72777

Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide

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