HPA004341

Anti-ASB6 antibody produced in rabbit

Name: Anti-ASB6 antibody produced in rabbit
Brand: SIGMA
Price: 71325 JPY

Prestige Antibodies^® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

別名:

Anti-ASB-6, Anti-Ankyrin repeat and SOCS box protein 6

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100 μL

￥71,325

単価￥95,100割引25%

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この商品について

UNSPSC Code:

12352203

NACRES:

NA.41

Human Protein Atlas Number:

HPA004341

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製品名

Anti-ASB6 antibody produced in rabbit, Prestige Antibodies^® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

product line

Prestige Antibodies^® Powered by Atlas Antibodies

form

buffered aqueous glycerol solution

species reactivity

human

technique(s)

immunoblotting: 0.04-0.4 μg/mL
immunohistochemistry: 1:50-1:200

immunogen sequence

IIFEYQPLVDAILGSLGIQDPERQESLDRPSYVASEESRILVLTELLERKAHSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFEDPVTYYTALHIAVLRNQPDMVELLVHHGADVNRRD

UniProt accession no.

Q9NWX5

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... ASB6(140459)

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当該品目	SAB1408893	SAB1105806	HPA003300
Sigma-Aldrich HPA004341 Anti-ASB6 antibody produced in rabbit	Sigma-Aldrich SAB1408893 Anti-ASB6 antibody produced in mouse	$Anti-ASB13 (215-225) antibody produced in rabbit IgG fraction of antiserum$ Sigma-Aldrich SAB1105806 Anti-ASB13 (215-225) antibody produced in rabbit	Sigma-Aldrich HPA003300 Anti-ASB7 antibody produced in rabbit
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
Quality Level 100	Quality Level 100	Quality Level 200	Quality Level 100
biological source rabbit	biological source mouse	biological source rabbit	biological source rabbit
antibody form affinity isolated antibody	antibody form purified immunoglobulin	antibody form IgG fraction of antiserum	antibody form affinity isolated antibody
product line Prestige Antibodies^® Powered by Atlas Antibodies	product line -	product line -	product line Prestige Antibodies^® Powered by Atlas Antibodies
form buffered aqueous glycerol solution	form buffered aqueous solution	form buffered aqueous solution	form buffered aqueous glycerol solution

Application

All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry.

The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies^® protocols and other useful information.

Biochem/physiol Actions

ASB (Ankyrin repeat and SOCS box containing 6) protein is involved in the ubiquitination-mediated pathway. The family members interact specifically with Cul5-Rbx2 in cells to form an E3 ubiquitin (Ub) ligase complex. But, it cannot interact with Cul2 and Rbx1 in the cells. It regulates components in the insulin signaling pathway by altering Asb6 degardation and Elongins BC.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Features and Benefits

Prestige Antibodies^® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies^® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:

IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
Protein array of 364 human recombinant protein fragments.

General description

ASB6 (Ankyrin repeat and SOCS box containing 6) is the orphan member of ankyrin repeat, SOCS box (ASB) family and the suppressor of cytokine signaling (SOCS) box protein superfamily. The family consists of 18 proteins named as ASB1 to ASB18. It is expressed in 3T3-L1 adipocytes as a 50-kDa protein.

Immunogen

Ankyrin repeat and SOCS box protein 6 recombinant protein epitope signature tag (PrEST)

Other Notes

Corresponding Antigen APREST86461

Physical form

Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide

Legal Information

Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany

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保管分類

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

最新バージョンのいずれかを選択してください：

試験成績書（COA）

Lot/Batch Number

R07578

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文書ライブラリで、最近購入した製品の文書を検索できます。

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Asb6, an adipocyte-specific ankyrin and SOCS box protein, interacts with APS to enable recruitment of elongins B and C to the insulin receptor signaling complex.

Andrew Wilcox et al.

The Journal of biological chemistry, 279(37), 38881-38888 (2004-07-03)

The APS adapter protein plays a pivotal role in coupling the insulin receptor to CAP and c-Cbl in the phosphatidylinositol 3-kinase-independent pathway of insulin-stimulated glucose transport. Yeast two-hybrid screening of a 3T3-L1 adipocyte library using APS as a bait identified

ASB proteins interact with Cullin5 and Rbx2 to form E3 ubiquitin ligase complexes.

Junya Kohroki et al.

FEBS letters, 579(30), 6796-6802 (2005-12-06)

The ankyrin repeat and SOCS box (ASB) family is composed of 18 proteins from ASB1 to ASB18 and belongs to the suppressor of cytokine signaling (SOCS) box protein superfamily. ASB2 was recently shown to interact with a certain Cul-Rbx module

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