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Merck

56485

Sigma-Aldrich

N-羟基硫代琥珀酰亚胺 钠盐

≥98% (HPLC), for peptide synthesis

别名:

磺基-NHS, 羟基-2,5-二氧代吡咯烷-3-磺酸 钠盐

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About This Item

经验公式(希尔记法):
C4H4NNaO6S
分子量:
217.13
Beilstein:
6359129
MDL號碼:
分類程式碼代碼:
12352005
PubChem物質ID:
NACRES:
NA.22

product name

N-羟基硫代琥珀酰亚胺 钠盐, ≥98% (HPLC)

化驗

≥98% (HPLC)

形狀

powder

成份

carbon, 21.57-22.68 (anhydrous)
nitrogen, 6.28-6.61 (anhydrous)

反應適用性

reaction type: Addition Reactions

雜質

≤4% water

應用

peptide synthesis

官能基

imide
sulfonic acid

SMILES 字串

[Na+].ON1C(=O)CC(C1=O)S([O-])(=O)=O

InChI

1S/C4H5NO6S.Na/c6-3-1-2(12(9,10)11)4(7)5(3)8;/h2,8H,1H2,(H,9,10,11);/q;+1/p-1

InChI 密鑰

RPENMORRBUTCPR-UHFFFAOYSA-M

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應用

N-羟基磺基琥珀酰亚胺钠盐是N-羟基琥珀酰亚胺的一种水溶性磺化类似物。它可以在碳二亚胺如1-乙基-3-(3-二甲基氨基丙基)碳二亚胺(EDC)存在时与羧酸发生偶联反应,形成亲水性的N-羟基磺基琥珀酰亚胺活性酯。这些酯可用于蛋白的交联实验。

包裝

无底玻璃瓶。内含物装在插入的融合锥内。

其他說明

磺基-NHS可用于制备亲水性活性酯,如用于交联剂

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


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N-hydroxysulfosuccinimide active esters: bis (N-hydroxysulfosuccinimide) esters of two dicarboxylic acids are hydrophilic, membrane-impermeant, protein cross-linkers.
Staros JV
Biochemistry, 21(17), 3950-3955 (1982)
Karen S Cheung Tung Shing et al.
Scientific reports, 8(1), 12457-12457 (2018-08-22)
A direct interaction between the erythropoietin (EPOR) and the beta-common (βc) receptors to form an Innate Repair Receptor (IRR) is controversial. On one hand, studies have shown a functional link between EPOR and βc receptor in tissue protection while others
R Maydelid Trujillo-Nolasco et al.
Materials science & engineering. C, Materials for biological applications, 103, 109766-109766 (2019-07-28)
Radiosynovectomy is a technique used to decrease inflammation of the synovial tissue by intraarticular injection of a β-emitting radionuclide, such as 177Lu, which is suitable for radiotherapy due to its decay characteristics. Drug-encapsulating nanoparticles based on poly lactic‑co‑glycolic acid (PLGA)
P S Anjaneyulu et al.
International journal of peptide and protein research, 30(1), 117-124 (1987-07-01)
N-Hydroxysulfosuccinimide esters are reactive functional groups employed in a variety of protein modification reagents, especially cross-linking reagents. For these compounds, hydrolysis is the most important reaction competing for reaction of the esters with nucleophilic groups in proteins. We have employed
Eloy Povedano et al.
Scientific reports, 8(1), 6418-6418 (2018-04-25)
This paper describes two different electrochemical affinity biosensing approaches for the simple, fast and bisulfite and PCR-free quantification of 5-methylated cytosines (5-mC) in DNA using the anti-5-mC antibody as biorecognition element. One of the biosensing approaches used the anti-5-mC as

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