SRP6122
AK2 human
recombinant, expressed in E. coli, ≥95% (SDS-PAGE)
Synonym(s):
ADK2, ATP-AMP phophotransferase, ATP-AMP transphosphorylase 2, Adenylate kinase 2, Adenylate monophosphate kinase
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About This Item
UNSPSC Code:
12352200
NACRES:
NA.32
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General description
Adenylate kinase (AK; adenosine triphosphate-adenosine monophosphate [ATP-AMP] phosphotransferase) is a ubiquitous monomeric enzyme involved energy metabolism of prokaryotic and eukaryotic cells. Three isozymes (AK1, AK2 and AK3) are characterized in vertebrates. Expression of these isozymes is tissue-specific and developmentally regulated. AK2 is localized in the mitochondrial intermembrane space and may play a role in apoptosis.
Physical form
1 mg/mL solution in 20 mM Tris-HCl buffer (pH 7.5) containing 5 mM DTT and 20% glycerol.
Preparation Note
Centrifuge the vial prior to opening.
Other Notes
MGSSHHHHHH SSGLVPRGSH MAPSVPAAEP EYPKGIRAVL LGPPGAGKGT QAPRLAENFC VCHLATGDML RAMVASGSEL GKKLKATMDA GKLVSDEMVV ELIEKNLETP LCKNGFLLDG FPRTVRQAEM LDDLMEKRKE KLDSVIEFSI PDSLLIRRIT GRLIHPKSGR SYHEEFNPPK EPMKDDITGE PLIRRSDDNE KALKIRLQAY HTQTTPLIEY YRKRGIHSAI DASQTPDVVF ASILAAFSKA TCKDLVMFI
signalword
Danger
hcodes
Hazard Classifications
Eye Dam. 1
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Ru-Ping Chen et al.
BMC molecular biology, 13, 31-31 (2012-10-02)
Adenylate kinase 2 (AK2) is a phosphotransferase that catalyzes the reversible reaction 2ADP(GDP) ↔ ATP(GTP) + AMP and influences cellular energy homeostasis. However, the role of AK2 in regulating cell proliferation remains unclear because AK2 has been reported to be involved in
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