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A6150

Sigma-Aldrich

α1-Antitrypsin from human plasma

salt-free, lyophilized powder

Synonym(s):

α1-Proteinase inhibitor

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About This Item

CAS Number:
9041-92-3
EC Number:
232-924-7
MDL number:
MFCD00130469
UNSPSC Code:
12352202
NACRES:
NA.77

biological source

human plasma

Quality Level

200

form

salt-free, lyophilized powder

concentration

≥60% (biuret)

technique(s)

inhibition assay: suitable

UniProt accession no.

P01009
P08246

storage temp.

2-8°C

Gene Information

human ... ELA2(1991) , ELANE(1991) , SERPINA1(5265)

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Biochem/physiol Actions

Serine protease inhibitor; inhibits trypsin, chymotrypsin and pancreatic and granulocytic elastase, and acrosin. Effective concentration equimolar with proteinase.The effects of hereditary α1-antitrypsin deficiency and certain autoimmune states result from uncontrolled proteolysis in vivo. Direct α1-antitrypsin replacement therapy has shown promise in animal models of Type 1 diabetes.
≤10 mg will inhibit 1.0 mg of trypsin with activity of 10,000 BAEE units per mg protein. ≤10 mg will inhibit approx. 1.0 mg of ·α-chymotrypsin with activity of 40-50 BTEE units per mg protein.

Caution

Aqueous stock solutions containing 0.01% NaN3 are stable for several months. Solutions can be stored at −80 °C, but should not be refrozen. Unstable below pH 5.5. Inactivated by some non-serine proteinases and by oxidation of active site methionine residue.

Preparation Note

Chromatographically prepared and partially purified.

Disclaimer

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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[Figure: see text].
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