TorsinA can regulate the cellular trafficking of the dopamine transporter, as well as other polytopic membrane-bound proteins, including G protein-coupled receptors, transporters, and ion channels. TorsinA is found in the dopamine neurons that are lost in PD, and is a component of Lewy bodies. in addition, a genetic defect in TorsinA underlies Torsion dystonia, a disease characterized by painful muscle contractions that result in uncontrollable distortions.
Specificity
TorsinA
Immunogen
Maltose binding protein fusion protein from human torsinA.
Application
Research Category Neuroscience
Research Sub Category Developmental Neuroscience
Neurodegenerative Diseases
This Anti-TorsinA Antibody is validated for use in IP, WB, IC for the detection of TorsinA.
Target description
37kDa
Physical form
Ascites
Liquid. Contaings no preservative
Storage and Stability
Maintain at -20°C in undiluted aliquots for up to 12 months after date of receipt. Avoid repeated freeze/thaw cycles.
Analysis Note
Control Positive Control: Human brain lysate, NGF treated PC12 cells.
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
wgk_germany
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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