Neuronal Pentraxins: A new family of putative integral membrane pentraxins or Neuronal pentraxins identified through interaction with a presynaptic snake venom toxin taipoxin. NPX1, NPX2 and NPXR (Neuronal Pentraxin Receptor), the three neuronal pentraxins represent a novel neuronal uptake pathway that may function during synapse formation and remodeling. The N-terminal half of neuronal pentraxins are 20-30% identical to previously identified pentraxins (CRP and SAP), the three neuronal pentraxins are 50% identical to each other and are significantly larger than the classical pentraxins (>50 versus 30kDa), suggesting that they may have additional novel functions. NPX1(Neuronal Pentraxin 1) a 432aa protein in mouse and rat, 430aa in human (chr 17q25). It mediates the uptake of degraded synaptic material which could play an important role in synaptic remodeling, expressed in brain.
Specificity
Neuronal pentraxin 1 (NPX1).
The immunogen sequence is 94% conserved in rat, and 82% in human NPX1.
Immunogen
Synthetic peptide near the N-terminus of mouse NPX1
Application
Research Category Neuroscience
Research Sub Category Synapse & Synaptic Biology
This Anti-Neuronal pentraxin 1 Antibody is validated for use in ELISA, WB, IH for the detection of Neuronal pentraxin 1.
Western blot: 1-10 µg/mL using ECL. Immunohistochemistry: Not tested. It is recommended that the antibody be tried at 2-20 µg/mL ELISA: 0.5-1 µg/mL using control peptide. Optimal working dilutions must be determined by end user.
Physical form
ImmunoAffinity Purified
Liquid in PBS with 0.1% BSA.
Storage and Stability
Maintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
wgk_germany
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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