peptide corresponding to amino acids 26-43 of rat p70 S6 Kinase, with an N-terminal cysteine
Application
Anti-p70 S6 Kinase Antibody is an antibody against p70 S6 Kinase for use in IP & WB.
Research Category Signaling
Research Sub Category PI3K, Akt, & mTOR Signaling
Quality
routinely evaluated by immunoblot in RIPA lysates from HEK293, PC-12,and A431 cells
Target description
64 kDa
Linkage
Replaces: 04-391
Physical form
0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30%
Format: Purified
Protein A purified
Storage and Stability
2 years at -20°C
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
wgk_germany
WGK 2
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Phosphotyrosine residues in the nerve-growth-factor receptor (Trk-A). Their role in the activation of inositolphospholipid metabolism and protein kinase cascades in phaeochromocytoma (PC12) cells.
Baxter, R M, et al.
European Journal of Biochemistry, 234, 84-91 (1995)
Protein phosphatase 2A inactivates the mitogen-stimulated S6 kinase from Swiss mouse 3T3 cells.
Ballou, L M, et al.
The Journal of Biological Chemistry, 263, 1188-1194 (1988)
A single gene encodes two isoforms of the p70 S6 kinase: activation upon mitogenic stimulation.
Reinhard, C, et al.
Proceedings of the National Academy of Sciences of the USA, 89, 4052-4056 (1992)
Human molecular genetics, 23(5), 1376-1386 (2013-10-24)
Spinobulbar muscular atrophy (SBMA) is an inherited neuromuscular disorder caused by the expansion of a CAG repeat encoding a polyglutamine tract in exon 1 of the androgen receptor (AR) gene. SBMA demonstrates androgen-dependent toxicity due to unfolding and aggregation of
The presence of cancer stem cells (CSCs) is linked to preexisting or acquired drug resistance and tumor relapse. Therefore, targeting both differentiated tumor cells and CSCs was suggested as an effective approach for non-small cell lung cancer (NSCLC) treatment. After
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