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A10507

Sigma-Aldrich

Acetone oxime

98%

Synonym(s):

β-Isonitrosopropane, 2-Propanone oxime, Acetoxime, Dimethyl ketoxime, N-Isopropylidenehydroxylamine, Propanone oxime

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About This Item

Linear Formula:
(CH3)2C=NOH
CAS Number:
127-06-0
Molecular Weight:
73.09
Beilstein/REAXYS Number:
1560146
EC Number:
204-820-1
MDL number:
MFCD00002118
UNSPSC Code:
12352100
PubChem Substance ID:
24890499
NACRES:
NA.02

assay

98%

form

crystals

bp

135 °C (lit.)

mp

60-63 °C (lit.)

density

0.901 g/mL at 25 °C (lit.)

SMILES string

C\C(C)=N/O

InChI

1S/C3H7NO/c1-3(2)4-5/h5H,1-2H3

InChI key

PXAJQJMDEXJWFB-UHFFFAOYSA-N

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signalword

Danger

Hazard Classifications

Acute Tox. 4 Dermal - Carc. 2 - Eye Dam. 1 - Flam. Sol. 2 - Skin Sens. 1B

Storage Class

4.1B - Flammable solid hazardous materials

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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N Guo et al.
Carcinogenesis, 11(9), 1659-1662 (1990-09-01)
The hepatocarcinogens 2-nitropropane and acetoxime have previously been found to induce a specific and qualitatively identical pattern of base damage in rat liver DNA and RNA, including the induction of increased levels of 8-hydroxyguanine. Because both 2-nitropropane and acetoxime are
S S Mirvish et al.
Cancer letters, 41(2), 211-216 (1988-08-15)
We tested the ability of phenobarbital and two liver carcinogens, acetoxime and 1-nitroso-5,6-dihydrouracil (NDHU), to induce hyperplastic liver nodules (HLN) in MRC-Wistar and Wistar rats, using a system that included a single diethylnitrosamine (DEN) treatment, partial hepatectomy, and administration of
C Kohl et al.
Carcinogenesis, 13(7), 1091-1094 (1992-07-01)
The hepatocarcinogenicity of acetoxime has been tentatively linked with its metabolic oxidation to the potent genotoxicant and carcinogen propane 2-nitronate (P2-N). In order to test the hypothesis that acetoxime is metabolized to P2-N, the oxime (20 mM) was incubated with
Stefanie Zorbas-Seifried et al.
Molecular pharmacology, 71(1), 357-365 (2006-10-20)
The presence of cis-configured exchangeable ligands has long been considered a prerequisite for antitumor activity of platinum complexes, but over the past few years, several examples violating this structure-activity relationship have been recognized. We report here on studies with the
P Kreis et al.
Carcinogenesis, 21(2), 295-299 (2000-02-05)
The industrial solvent 2-nitropropane (2-NP) is a genotoxic hepatocarcinogen in rats. The genotoxicity of the compound in rats has been attributed to sulfotransferase-mediated formation of DNA-reactive nitrenium ions from the anionic form of 2-NP, propane 2-nitronate (P2N). Whether human sulfotransferases
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