Methanesulfonamide is used in the synthesis of important organic reagents such as N-(2-methylthio-1-p-toluenesufonyl)methanesulfonamide and tert-butyl ((2-(trimethylsilyl)ethyl)sulfonyl)carbamate.[1]
It can be used as a source of nitrogen in the conversion of carboxylic acids to corresponding nitriles.[2]
It is widely used as a reagent in the synthesis of medicinally important compounds such as derivatives of indole-N-acetamide[3], methanesulfonamide pyrimidine-substituted 3,5-dihydroxy-6-heptenoates[4] and repertaxin[5].
Synthesis and biological activity of methanesulfonamide pyrimidine-and N-methanesulfonyl pyrrole-substituted 3, 5-dihydroxy-6-heptenoates, a novel series of HMG-CoA reductase inhibitors.
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