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20224AST

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Astec® CYCLOBOND I 2000 SP Chiral (5 μm) HPLC Columns

L × I.D. 25 cm × 4.6 mm, HPLC Column

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About This Item

UNSPSC Code:
41115700
eCl@ss:
32110501
NACRES:
SB.52

Product Name

Astec® CYCLOBOND I 2000 SP Chiral HPLC Column, 5 μm particle size, L × I.D. 25 cm × 4.6 mm

material

stainless steel column

product line

Astec®

packaging

pkg of 1 ea

manufacturer/tradename

Astec®

parameter

0-50 °C temperature
172 bar pressure (2500 psi)

technique(s)

HPLC: suitable
LC/MS: suitable

L × I.D.

25 cm × 4.6 mm

matrix

silica particle platform
fully porous particle

matrix active group

cyclodextrin, beta- phase

particle size

5 μm

pore size

100 Å

operating pH

3.5-7

separation technique

chiral

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General description

On CYCLOBOND I 2000 SP, the hydroxyl groups on the surface of the β-cyclodextrin have been reacted with (S)-propylene oxide. This has the effect of extending hydrogen-bonding capabilities to accommodate analytes with chiral centers that are relatively distant from an aromatic ring structure. The (S)- form shows enhanced selectivity and efficiency for some separations, methadone, for example.

  • Bonded phase: (S)-Hydroxypropyl modified β-cyclodextrin

Resources:
CYCLOBOND FAQs
CYCLOBOND Reference Bibliography
Chiral Product Literature

Other Notes

Recommended alternative 20024AST ASTEC® CYCLOBOND 2000 Chiral HPLC Column
See technical report

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Legal Information

Astec is a registered trademark of Merck KGaA, Darmstadt, Germany

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Certificates of Analysis (COA)

Lot/Batch Number
268608-02
268608-01
268603-02
268603-01
268575-02

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High-performance liquid chromatographic determination of the isomeric purity of a series of dioxolane nucleoside analogues
Di Marco, M.P., et al.
Journal of Chromatography A, 645 (1), 107-114 (1993)
Chuong Pham-Huy et al.
Journal of biochemical and biophysical methods, 54(1-3), 287-299 (2003-01-25)
The enantioselective high-performance liquid chromatography (HPLC) of three racemic 3-hydroxybenzodiazepines, oxazepam (Oxa), lorazepam (Lor), and temazepam (Tem), is a difficult operation because of the spontaneous chiral inversion in polar solvent. To solve this problem, we have developed an HPLC method

Related Content

Astec CYCLOBOND™

CYCLOBOND is the name given to Astec technology for bonding cyclodextrins to a high purity silica gel through a stable ether linkage.

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