T1428
apo-Transferrin bovine
BioReagent, suitable for cell culture, ≥98%
Synonym(s):
Human serotransferrin
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About This Item
Recommended Products
biological source
bovine
product line
BioReagent
assay
≥98%
form
powder
technique(s)
cell culture | mammalian: suitable
impurities
iron, essentially free
solubility
H2O: 10 mg/mL
UniProt accession no.
storage temp.
2-8°C
Gene Information
bovine ... TF(280705)
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General description
apo-Transferrin is an iron-free form of transferrin that is present in circulation.
Application
All cells require iron for the proper uptake of oxygen from their environment. Transferrin, a protein isolated from serum, causes the uptake and transport of iron from culture medium to the cells. This allows proper oxygen uptake and also stimulates growth-related enzyme activity. Iron-saturated transferrin (holo transferrin) is continually recycled after releasing iron and becomes iron-deficient transferrin (apo-transferrin). Choosing which form to use depends upon the culture conditions. In media such as Dulbecco′s Modified Eagle′s Medium/Ham′s Nutrient Mixture F12 (DMEM/F12) that contain high levels of iron salt, using apo-transferrin is preferred.
apo-Transferrin bovine has been used as a component of:
- basal medium for culturing bovine mammary epithelial cells
- minimum essential medium α (MEM-α) for spermatogonial stem cells (SSCs) culture
- induction medium for mesenchymal stem cell culture
Biochem/physiol Actions
apo-Transferrin (apoTf) aids in preventing iron accumulation in tissues, especially in non-transfusion dependent β-thalassemia.
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Certificates of Analysis (COA)
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Zeitschrift fur Naturforschung. C, Journal of biosciences, 63(1-2), 154-156 (2008-04-05)
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