SRP8059

Jagged-2 (human): FC (human)

recombinant, expressed in HEK 293 cells, ≥90% (SDS-PAGE)

• Synonym(s): Alpha-ketoglutarate-dependent dioxygenase FTO, Protein jagged-2, hJ2
• UNSPSC Code: 12352200
• NACRES: NA.32

Properties

• recombinant: expressed in HEK 293 cells
• assay: ≥90% (SDS-PAGE)
• form: lyophilized
• mol wt: ~150 kDa by SDS-PAGE
• impurities: <0.1 EU/μgtested
• UniProt accession no.: Q9Y219
• shipped in: wet ice
• storage temp.: −20°C
• Gene Information: human ... JAG2(3714)

Description

General description

Jagged-2 is a putative Notch ligand involved in the mediation of Notch signaling, that can induce stromal cells to secrete IL-6, VEGF and IGF-1. Notch activation can interact with NF-kappaB and C-myc to promote the proliferation and to inhibit the apoptosis of MM cells, showing in the relationship between the incidence of myeloma and drug resistance. Jagged-2 is also involved in limb development.

Sequence

Human Jagged-2 (aa 1-1054) is fused at the C-terminus to the Fc portion of human IgG.

Physical form

Lyophilized. Contains PBS + 0.02 % CHAPS.

Reconstitution

Reconstitute with 100μl sterile water.

Safety Information

• Storage Class: 12 - Non Combustible Liquids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable