I141
Intralipid
emulsion, lipid emulsion
Synonym(s):
Phospholipid stabilized soybean oil
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Product Name
Intralipid, 20%, emulsion
form
emulsion
Quality Level
concentration
20%
color
white
storage temp.
2-8°C
Application
Intralipid has been used:
- for testing its optical properties to be used as scattering medium for tissue phantom generation
- as a component of agarose gel phantom to reduce scatter coefficients and background absorption
- in infusion into mice in hyperinsulinemic-euglycemic clamps studies to evaluate its effect on nonesterified free fatty acids (NEFA) circulation
Biochem/physiol Actions
Intralipid is a lipid emulsion comprising soybean oil. It favors proinflammatory cytokines production and is recommended for the treatment of immune-mediated pregnancy and implantation failure. In parenteral nutrition, intralipid is the source of fats. It elicits protection in heart ischemia-reperfusion injury by inhibiting mitochondrial permeability transition pore opening. Intralipid is an effective alternative for intravenous immunoglobulin and improves bioavailability of platinum based anti-cancer drugs.
Storage Class
10 - Combustible liquids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves
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Broadband spectroscopy for characterization of tissue-like phantom optical properties
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Polish journal of medical physics and engineering, 23(4), 121-126 (2017)
The Importance of Intralipid in Heart Protection: A Brief Review
Dizaj SM
Journal of Anesthesia and Surgery, 4(1), 0-0 (2017)
Sean R Donohue et al.
Journal of medicinal chemistry, 51(18), 5833-5842 (2008-09-20)
We have reported that [methyl- (11)C] (3 R,5 R)-5-(3-methoxyphenyl)-3-[(R)-1-phenylethylamino]-1-(4-trifluoromethylphenyl)pyrrolidin-2-one ([(11)C] 8, [(11)C]MePPEP) binds with high selectivity to cannabinoid type-1 (CB 1) receptors in monkey brain in vivo. We now describe the synthesis of 8 and four analogues, namely, the 4-fluorophenyl
Intralipid, a clinically safe compound, protects the heart against ischemia-reperfusion injury more efficiently than cyclosporine-A
Li J, et al.
Anesthesiology, 117(4), 836-846 (2012)
Novel metabolic disorders in skeletal muscle of Lipodystrophic Bscl2/Seipin deficient mice
Xu W, et al.
Molecular and Cellular Endocrinology, 482(22), 1-10 (2019)
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