SRP6187
Eosinophil Peroxidase human
≥95% (SDS-PAGE)
Synonym(s):
EPER, EPO, EPP
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About This Item
UNSPSC Code:
12352200
NACRES:
NA.32
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General description
Native, human eosinophil peroxidase is a secreted hemoprotein that catalyzes oxidations of various substrates by hydrogen peroxide. Together with other leukocyte-derived enzymes, such as Myeloperoxidase, EPO plays an important role in the pathogenesis of asthma by mediating oxidative events that lead to the production of ROS (reactive oxygen species) and RNS (reactive nitrogen species).
Physical form
Lyophilized from 20 mM NaH2PO4, pH 7.5, and 150 mM NaCI.
Reconstitution
Reconstitute in deionized H₂O. Aliquot and store at –20°C. Avoid freeze-thaw cycles.
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Jorge Sánchez et al.
Allergy, asthma & immunology research, 13(5), 746-761 (2021-09-07)
Eosinophils are frequently found in atopic dermatitis (AD) and chronic spontaneous urticaria (CSU) that release eosinophil peroxidase (EPX) and eosinophil cationic protein (ECP). Continuous exposure to these proteins could trigger an autoimmune response which may contribute to the pathogenesis and
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