SML0967

TAE-1

≥98% (HPLC)

• Synonym(s): 2,2′,2′-[1,3,5-Triazine-2,4,6-triyltris(oxy-4,1-phenylenecarbonyloxy)]tris[N,N,N-trimethyl-ethanaminium tri-iodide
• Empirical Formula (Hill Notation): C₃₉H₅₁N₆O₉ · 3I
• CAS Number: 1414469-59-2
• Molecular Weight: 1128.57
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated
• color: white to beige
• solubility: H₂O: 5 mg/mL, clear (warmed)
• storage temp.: 2-8°C

Description

Biochem/physiol Actions

TAE-1 is an inhibitor of amyloid-β fibril formation and aggregation. TAE-1 also inhibits cholinesterases AChE and BuChE.

TAE-1 is an inhibitor of amyloid-β fibril formation and aggregation. TAE-1 is a sym-triazine with dual activity against Alzheimer′s disease. TAE-1 inhibits cholinesterases AChE and BuChE with IC₅₀ values of 0.3 and 3.9 μM. Studies using TAE-1 on differentiated human SH-SY5Y neuronal cells have suggested that it can stimulate synapse formation and promote the differentiation of human neurons, increasing neurite extension.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Safety Information

• Storage Class: 13 - Non Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable