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Key Documents

SML0738

Sigma-Aldrich

RORγ Activator 1b

≥98% (HPLC)

Synonym(s):

N-(4,6-Dimethyl-2-benzothiazolyl)-3-methyl-2-thiophenecarboxamide

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5 MG
$70.70
25 MG
$286.00

About This Item

Empirical Formula (Hill Notation):
C15H14N2OS2
CAS Number:
Molecular Weight:
302.41
UNSPSC Code:
12352200
NACRES:
NA.77

$70.70


Available to ship onMay 02, 2025Details


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assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 20 mg/mL, clear

storage temp.

2-8°C

Biochem/physiol Actions

RORγ Activator 1b binds to the retinoid-related orphan receptor RORγ and induces IL-17 reporter gene expression with an EC50 of 0.1 μM. The compound RORγ Activator 1b enhances differentiation of CD4+ T cells to IL-17-secreting cells with a maximum effect of 220 percent of control at 3 μM.
RORγ Activator 1b binds to the retinoid-related orphan receptor RORγ and induces IL-17 reporter gene expression.

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Warning

hcodes

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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