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Key Documents

SML0730

Sigma-Aldrich

PCNA-I1

≥98% (HPLC)

Synonym(s):

N-(3-Methylthiophene-2-carboxylic acid)-N′-[(3-hydroxy-2-naphthalenyl)methylene]hydrazide

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5 MG
$101.65

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5 MG
$101.65

About This Item

Empirical Formula (Hill Notation):
C17H14N2O2S
CAS Number:
1364915-48-9
Molecular Weight:
310.37
UNSPSC Code:
12352200
NACRES:
NA.77

$101.65

List Price$107.00
Web-Only Promotion

Available to ship onApril 29, 2025Details

Request a Bulk Order

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 10 mg/mL, clear

storage temp.

2-8°C

Related Categories

Biochem/physiol Actions

PCNA-I1 is a PCNA inhibitor.
PCNA-I1 is a small molecule PCNA inhibitor that selectively binds to PCNA trimers and reduces the association of PCNA with chromatin. PCNA-I1 induces S and G2/M phase cell cycle arrest in tumor cells with greater efficacy than non-transformed cells.
Proliferating cell nuclear antigen-l1 (PCNA) is a member of the scaffold B class.[1] It acts as a linker at the monomer-monomer interface. PCNA-I1 has the ability to block the development of primary cultures of bone marrow mesenchymal stem cells, endothelial cells, lymphocytes, mammary epithelial cells and prostate epithelial cells.[2]

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000407151
0000407151
0000178594
083M4728V

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Small molecule targeting of PCNA chromatin association inhibits tumor cell growth
Tan Z, et al.
Molecular Pharmacology, mol-112 (2012)
Target validation and structure-activity analysis of a series of novel PCNA inhibitors
Dillehay KL, et al.
Pharmacology Research & Perspectives, 3(2), e00115-e00115 (2015)

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