Hormone sensitive lipase (HSL) is coded by LIPE (lipase E) gene. It is an intracellular lipase with substrates as triglycerides, diglycerides, monoglycerides, cholesterol esters and retinyl esters. HSL is mapped to human chromosome 19q13.
Immunogen
The antiserum was produced against synthesized peptide derived from human HSL around the phosphorylation site of Ser552.
Immunogen Range: 518-567
Application
Anti-HSL antibody has been used in western blotting.
Biochem/physiol Actions
Hormone sensitive lipase (HSL) plays an important role in lipolysis. Lack of HSL results in histologic abnormalities in white adipose tissue and an increase in macrophage infiltration.
Features and Benefits
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Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Progesterone-induced down-regulation of hormone sensitive lipase (Lipe) and up-regulation of G0/G1 switch 2 (G0s2) genes expression in inguinal adipose tissue of female rats is reflected by diminished rate of lipolysis
Stelmanska E, et al.
The Journal of Steroid Biochemistry and Molecular Biology, 147, 31-39 (2015)
Identification of microdeletions spanning the Diamond-Blackfan anemia locus on 19q13 and evidence for genetic heterogeneity
Gustavsson P, et al.
American Journal of Human Genetics, 63(5), 1388-1395 (1998)
Null mutation in hormone-sensitive lipase gene and risk of type 2 diabetes
Albert JS, et al.
The New England Journal of Medicine, 370(24), 2307-2315 (2014)
Molecular medicine (Cambridge, Mass.), 29(1), 33-33 (2023-03-16)
Caveolin-1 has been predicted, based on RNA transcriptome sequencing, as a key gene in rotator cuff tear (RCT) and it is related to fatty infiltration. This study aims to elucidate the upstream and downstream mechanism of Caveolin-1 in fatty infiltration
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