SAB4300173

Anti-phospho-PTK2B (pTyr⁴⁰²) antibody produced in rabbit

affinity isolated antibody

• Synonym(s): Anti-CADTK antibody produced in rabbit, Anti-CAKB antibody produced in rabbit, Anti-FADK2 antibody produced in rabbit, Anti-FAK2 antibody produced in rabbit, Anti-PTK2B protein tyrosine kinase 2 beta antibody produced in rabbit
• MDL number: MFCD01634069
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: ~116 kDa
• species reactivity: human, rat, mouse
• concentration: 1 mg/mL
• technique(s): immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100; indirect immunofluorescence: 1:100-1:200; western blot: 1:500-1:1000
• isotype: IgG
• immunogen sequence: (D-I-YP-A-E)
• NCBI accession no.: NP_004094.3
• UniProt accession no.: Q14289
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: phosphorylation (pTyr402)
• Gene Information: human ... PTK2B(2185)

Description

General description

Protein tyrosine kinase 2β (PTK2B) is a member of the focal adhesion kinase family which is expressed in the brain. The gene encoding it is localized on human chromosome 8.

Immunogen

Peptide sequence around phosphorylation site of tyrosine 402 (D-I-Y(p)-A-E), according to the protein PTK2B.

Biochem/physiol Actions

Protein tyrosine kinase 2 β (PTK2B) takes part in the β₂-mediated signaling pathway and activates mitogen activated protein kinase pathway. The protein has been shown to be upregulated in many tumors. PTK2B also has a role in cell proliferation and migration. It regulates ion channels which are induced by calcium.

Features and Benefits

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Target description

Involved in calcium induced regulation of ion channel and activation of the map kinase signaling pathway. May represent an important signaling intermediate between neuropeptide activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. Interacts with the SH2 domain of Grb2. May phosphorylate the voltage-gated potassium channel protein Kv1.2. Its activation is highly correlated with the stimulation of c-Jun N-terminal kinase activity. Involved in osmotic stress-dependent SNCA 'Tyr-125' phosphorylation.

Physical form

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class: 12 - Non Combustible Liquids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable