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SAB4300141

Sigma-Aldrich

Anti-phospho-PRKAA1 (pSer487) antibody produced in rabbit

affinity isolated antibody

Synonym(s):

Anti-AMPK antibody produced in rabbit, Anti-AMPKa1 antibody produced in rabbit, Anti-MGC33776 antibody produced in rabbit, Anti-MGC57364 antibody produced in rabbit, Anti-protein kinase, AMP-activated, alpha 1 catalytic subunit antibody produced in rabbit

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

~63 kDa

species reactivity

human

concentration

1 mg/mL

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100
indirect immunofluorescence: 1:100-1:200
western blot: 1:500-1:1000

isotype

IgG

immunogen sequence

(S-G-SP-V-S)

NCBI accession no.

NP_006242.5

UniProt accession no.

Q13131

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

phosphorylation (pSer487)

Gene Information

human ... PRKAA1(5562)

Immunogen

Peptide sequence around phosphorylation site of serine 487 (S-G- SP-V-S), according to the protein PRKAA1.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Target description

Responsible for the regulation of fatty acid synthesis by phosphorylation of acetyl-CoA carboxylase. It also regulates cholesterol synthesis via phosphorylation and inactivation of hormone-sensitive lipase and hydroxymethylglutaryl-CoA reductase. Appears to act as a metabolic stress-sensing protein kinase switching off biosynthetic pathways when cellular ATP levels are depleted and when 5'-AMP rises in response to fuel limitation and/or hypoxia. This is a catalytic subunit.

Physical form

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
871511174

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Fan Bai et al.
Lipids in health and disease, 18(1), 109-109 (2019-05-12)
Atrial lipid metabolic remodeling is critical for the process of atrial fibrillation (AF). Abnormal Fatty acid (FA) metabolism in cardiomyocytes is involved in the pathogenesis of AF. MET (Metformin), an AMPK (AMP-activated protein kinase) activator, has been found to be
Minsu Jang et al.
Scientific reports, 8(1), 12637-12637 (2018-08-25)
AMP-activated protein kinase (AMPK) regulates autophagy initiation when intracellular ATP level decreases. However, the role of AMPK during autophagosome maturation is not fully understood. Here, we report that AMPK contributes to efficient autophagosome maturation and lysosomal fusion. Using CRISPR-Cas9 gene
Wenfeng Liu et al.
Experimental gerontology, 124, 110647-110647 (2019-07-01)
The objective was to analyze the effects of aerobic exercise on aging striatum stress resistance, and the adaptive mechanisms related to neurodegenerative diseases, and the occurrence, and development of neural degeneration. The 10-weeks of regular moderate-intensity aerobic exercise intervention were
Alicia Bort et al.
PloS one, 14(1), e0211420-e0211420 (2019-01-30)
Capsaicin is a natural compound present in chili and red peppers and the responsible of their spicy flavor. It has recently provoked interest because of its antitumoral effects in many cell types although its action mechanism is not clearly understood.
Wei-Guo Ma et al.
Chinese journal of integrative medicine, 25(3), 182-189 (2017-12-30)
To observe the effects of Chinese medicine (CM) Polygonum cuspidatum (PC) on adenosine 5'-monophosphate-activated protein kinase (AMPK), forkhead box O3α (FOXO3α), Toll-like receptor-4 (TLR4), NACHT, LRR and PYD domains-containing protein 3 (NLRP3), and monocyte chemoattractant protein-1 (MCP-1) expression in a

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