SAB4200429
Anti-PIWIL4 antibody produced in rabbit
~1.0 mg/mL, affinity isolated antibody
Synonym(s):
Anti-HIWI2, Anti-MIWI2, Anti-Piwi-like 4
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~95 kDa
species reactivity
human
concentration
~1.0 mg/mL
technique(s)
western blot: 0.5-1.0 μg/mL using lysates of HEK-293Tcells overexpressing human PIWIL4.
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... PIWIL4(143689)
General description
P-element Induced WImpy testis (PIWI)-like 4 (PIWIL4) protein belongs to the PIWI subfamily. This protein is localized in tumorous colon tissues. PIWIL4 gene is located on the human chromosome at 11q21.
Specificity
Anti-PIWIL4 recognizes human PIWIL4.
Immunogen
peptide corresponding to an internal region of human PIWIL4, conjugated to KLH. The corresponding sequence differs by a single amino acid in mouse and rat.
Application
Anti-PIWIL4 antibody produced in rabbit may be used in immunoblotting.
Biochem/physiol Actions
P-element Induced WImpy testis (PIWI)-like 4 (PIWIL4) protein promotes tumorigenesis and cell invasion. It is expressed in several cancers like colon and breast cancer. This protein enhances cell growth and blocks apoptosis in cervical cancer cells. PIWIL4 protein is also involved in the chromatin-modifying pathway of human somatic cells. Mutation in the PIWIL4 gene is associated with breast cancer.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Storage and Stability
For continuous use, store at 2-8 °C for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing, or storage in “frost-free” freezers,is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
wgk_germany
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Chang Su et al.
FEBS letters, 586(9), 1356-1362 (2012-04-10)
Recently, PIWIL4 has been identified as a functional protein involved in tumorigenesis. Cervical cancer is the second most prevalent form of cancer worldwide. The relationship between PIWIL4 and cervical cancer is still unknown. Here, we found that PIWIL4 is up-regulated
Kaipeng Xie et al.
Journal of ovarian research, 12(1), 1-1 (2019-01-06)
Ovarian cancer remains the most fatal gynecologic malignancy worldwide due to delayed diagnosis as well as recurrence and drug resistance. Thus, the development of new tumor-related molecules with high sensitivity and specificity to replace or supplement existing tools is urgently
Keiki Sugimoto et al.
Biochemical and biophysical research communications, 359(3), 497-502 (2007-06-05)
The field of epigenetics has made progress by the identification of the small RNA-mediated epigenetic modification. However, little is known about the key proteins. Here, we report that the human PIWI-like family is a candidate protein that is involved in
Zifeng Wang et al.
The Journal of biological chemistry, 291(20), 10646-10658 (2016-03-10)
P-element-induced wimpy testis (PIWI) proteins bind to PIWI-interacting RNAs and play key roles in the biogenesis and functions of PIWI-interacting RNAs. It has been reported that PIWI proteins are essential for stem cell self-renewal and germline development in diverse organisms
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